23-24 May, 2012 - Basel, Switzerland
Mercure Hotel Europe Basel,
Clarastrasse 43,
Postfach,
CH-4005 Basel,
Tel: +41 61 690 8080
Price: US$1275
The central tenant of Quality by Design (ICH Q8) is that quality cannot be tested into a product – instead it must be designed into the product. When the product is an HPLC method, QbD strategies can guide the development process to result in a standardized method development process, more easily validated methods, and methods that are easier to use and adjust in routine applications.
This 2- day class is designed for laboratory workers involved in HPLC method development as well as those who must transfer of existing methods into a routine laboratory. The class focuses on separation fundamentals and applies them in a time-proven strategy that applies QbD principles to developing robust HPLC methods quickly. Based on the instructor’s extensive experience in a laboratory supporting pharmaceutical and bioanalytical methods, the attendees should gain practical skills to develop realistic HPLC methods in a short time. The techniques can be used as a stand-alone strategy or added to existing development procedures to help streamline the process. The course content assumes a basic understanding of HPLC, but not necessarily experience in method development. Students will be introduced to HPLC method development software to help find satisfactory separation conditions. Attendees will receive a comprehensive set of course notes, including copies of all visual materials presented.
Day 1
Section 1 – Introduction to HPLC Method Development
Section 2 – HPLC Basics
Section 3 – HPLC Columns
Section 4 – Reversed-Phase Separation
Section 5 – Dealing with Ionic Samples
Section 6 – Ion Pair Chromatography
Day 2
Section 7 – Gradient Elution
Section 8 – Quality by Design
Section 9 -- Normal Phase and HILIC
Section 9 -- Quality Issues
Bonus Options
Chiral Separations
Ion-Exchange Chromatography
HPLC – UHPLC tradeoffs
Quality Issues
LC-MS
Sample Preparation
The normal class covers Sections 1-9. Depending on the interests of the particular group of attendees and the remaining time, one or more of the Bonus topics may be included. Each student receives a course notebook, which contains copies of all the slides used in the class plus a written summary of the key points for each slide.
This course makes use of chromatography simulation software as a teaching tool. Course attendees will use the software to develop methods using the principles discussed during the lectures. The principles used in computer modeling are fully applicable to separations in your lab. You will learn how to do the best possible chromatography. Save hours of frustration and improve your results time after time.
Our main goal is not to get through a canned curriculum, but to provide practical help to attendees that can be applied in real situations in the lab. Students are encouraged to bring questions, separations problems, and other topics of interest to discuss during the class or one-on-one with the instructor.
About the sponsor
LCC was formed in 1995 by Irene and Willi Glettig to sell HPLC columns and chromatography consumables in Switzerland and offer the very best technical service available. LCC represent the most reputable HPLC specialists including Hichrom and ACT (ACE) and can supply about 90% of all leading brands of HPLC columns. We are proud to work with companies in the fields of Pharmaceutical Research, Process Development, Med-Tech, Biotech, Biopharmaceutical, Biogenerics, Generic Pharmaceutical, Fine Chemicals Manufacturer, Performance Chemicals, Food Technology and Diagnostics manufacturers.
Please email any questions to jackie.tan@sepscience.com.
To register for this workshop simply complete the form below:
10% Discount when courses are booked together.