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Changing from Helium to Nitrogen and Maintaining the Separation Efficiency in the Same Analysis Time

by Jaap de Zeeuw and Jack Cochran, Restek Corporation.

For several reasons, there is interest in replacing helium with a different carrier gas in GC. Hydrogen is the obvious choice but there is concern on safety and reactivity. It is also possible to use nitrogen but this is often not considered because it has a low optimal flow and velocity. Here we will show that it is possible to replace helium with nitrogen as the carrier gas while separation, peak elution order, analysis time, response and even oven temperature conditions can be kept the same.


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