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SFC Solutions


SFC Solutions


SFC Solutions

SFC Solutions: Enantioselective Resolution and Analysis of Chiral Pesticides in Formulations by UltraPerformance Convergence Chromatography

Analytical method development for the separation of chiral compounds is important in many areas of research because it is known that enantiomers can exhibit different biological activity. The study of enantioselectivity is important to the agricultural chemicals manufacturing industry since the knowledge of the efficacy of each individual enantiomer could facilitate a significant reduction in the total amount of pesticide applied.


SFC Solutions #4: Reaction Monitoring with UltraPerformance Convergence Chromatography

In this article we will discuss the use of UltraPerformance Convergence Chromatography (UPC2) coupled with mass spectrometry for monitoring and optimization of several synthetic routes of three pharmaceutical active ingredients. We will discuss the utility of UPC2 for chiral and achiral separations, synthetic route optimization, and separation orthogonality compared to common reversed-phase liquid chromatography (RPLC).


SFC Solutions #3: Using Convergence Chromatography for Natural Product Analysis and Purification

UltraPerformance Convergence Chromatography (UPC2) is a separation technique that uses compressed carbon dioxide as the primary mobile phase. It takes advantage of sub-two micron particle chromatography columns and an advanced chromatography system design to achieve fast and reproducible separation with high efficiencies and unique selectivity. It also generates much lower solvent wastes as compared to liquid chromatography (LC). Examples of using UPC2 for fat-soluble vitamins (FSV) are presented here to illustrate the advantages of UPC2 technology over current techniques in SFV analysis.


SFC Solutions #1: Practical Considerations for Achiral Analysis of Pharmaceutical Compounds Using Convergence Chromatography

In convergence chromatography (CC), the modes of interaction between the stationary phase and the solute are numerous, including hydrogen bonding, hydrophobic interactions, dipolar and polarizability interactions and solute partitioning. In this article we will describe some practical considerations for the analysis of pharmaceutical compounds by convergence chromatography.