In many analytical workflows, solid sample analysis remains a slow and laborious process. Traditional methods require digestion, dilutions, columns, and specialized laboratory infrastructure, which create barriers that lengthen turnaround times and limit access to high-quality elemental data. Laser ablation laser ionization time-of-flight mass spectrometry (LALI-TOF-MS) signals a shift in this landscape, offering a compact, consumable-free alternative that delivers fast and reproducible results across complex matrices.
Overcoming Workflow Barriers with Laser Ablation Laser Ionization
Jeff Williams, CEO/CTO and Founder of Exum Instruments, developed the technology after encountering years of frustration with conventional instrumentation. He recalls his experience working with tools such as inductively coupled plasma mass spectrometry (ICP-MS), laser ablation systems, and microprobes, systems that were inconvenient to operate and required significant time and expertise to produce actionable data. That frustration sparked the development of a simplified platform that delivers full elemental analysis directly from solids with no digestion or specialized lab setup required.
The key lies in a two-laser system. “The first laser ablates the sample to create a cloud of neutral particles,” explains Williams. “A second laser then ionizes the particles, which are directed into a time-of-flight mass spectrometer.” This setup delivers complete elemental data for every pixel scanned, from lithium to uranium. Unlike plasma-based techniques such as laser-induced breakdown spectroscopy (LIBS), the system avoids matrix-dependent complications and supports accurate quantitation with detection limits in the parts-per-billion range.
Advantages of LALI-TOF-MS
Williams emphasizes the accessibility of the LALI-TOF-MS approach. The instrument requires only a standard 110V outlet and occupies just a couple feet of bench space. “No consumables, no argon gas, no special requirements,” advises Williams. “You can have it running right next to a power source for additive manufacturing—it doesn’t need to be in a clean lab.” He adds that training takes only a few hours, and users can be up and running within a day of installation.
For labs already using ICP-MS, the benefits are immediate. Entire wet chemistry labs, with their acids, columns, and trained specialists, can be replaced by a box and a power cord. Williams explains that engineers or technicians can operate the system independently, allowing for more efficient use of staff and resources. “That’s a big shift to operating budgets and capital costs.”
Key Applications of LALI-TOF-MS
In the battery sector, the dual-laser system unlocks capabilities that weren’t previously available. Williams points to the difficulty of measuring lithium with other techniques, especially in two or three dimensions. With this method, users can create full 3D reconstructions of lithium distribution, visualize plating or degradation issues, and study the evolution of the SEI (Solid Electrolyte Interface) layer, all of which are critical for advancing battery design and reliability.
The mining and geochemical sectors have also taken an interest, with potential applications in in-field decision-making. In one recent study on behalf of a customer, samples were analyzed at multiple densities, ranging from loosely pressed powder to powder pelletized with nine-ton compaction. Conventional methods returned variable results, but the new system produced consistent data across all densities. “Density differences cause dramatically different results in traditional techniques,” says Williams, “but our system’s results were the same every time.”
Looking Ahead: A Future Built on Simplicity and Speed
Adoption has grown rapidly, with global representation expanding across Australia, Korea, Canada, and the United States. The technology’s ease-of-use and measurable gains in efficiency are driving most of the traction. As Williams notes, the goal was always to empower the person on the bench—the one solving problems, optimizing workflows, and asking for better tools. “If you want to run more samples, improve accuracy, or offer more services, this is the tool you need.”
Indeed, LALI-TOF-MS is now used daily in labs across several industries and is stable and production-ready. While improvements are always underway, Williams says the current platform has met the original vision: it provides fast, reliable, and simple solid sample analysis without the burdens of traditional workflows.