Adeno-associated virus (AAV) production generates a mixture of empty, partially full, and full capsids. These populations can share similar physical and chemical properties, making accurate characterization and separation a persistent challenge. Effective analysis remains critical for controlling product potency, purity, and immunogenicity risk.
This infographic compares four technologies used for AAV capsid characterization: sedimentation velocity analytical ultracentrifugation (SV-AUC), mass photometry, charge detection mass spectrometry (CDMS), and anion exchange chromatography (AEX-HPLC). Explore their relative speed, sample requirements, data outputs, and resolution capabilities. You will also see how biophysical mass profiling and chromatographic separation provide complementary insights into capsid composition.
Complete the form to download the infographic now.