[On-Demand Webinar] Accelerating Large Molecule LC-MS Method Development

by | Articles, Pharmaceutical Analysis

Rapid development of sensitive and selective peptide bioanalytical methods are required to support the expanding protein component of pharmaceutical companies’ drug pipeline. Choosing the best MRM for a large molecule peptide or protein is a challenge because multiple charge states are possible, and the many production possibilities leave many MRMs to be screened.

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Manual tuning is tedious, and optimizing for sensitivity via LC injections is time-consuming when monitoring multiple MRMs per peptide, and multiple peptides per protein.

Learning Outcomes

  • Learn the advantages of an automated workflow for large molecule characterization and optimization.
  • Receive an overview of how to use DiscoveryQuant™ software for peptide tuning and optimization.

Ian_Moore_HeadshotIan Moore is Global Technical Marketing Manager for Pharma applications at SCIEX, based in Toronto, Canada. Ian has many years of experience in bioanalytical method development and validation in both a pharmaceutical and CRO environment. He joined SCIEX in 2012, and has been recently focused on the development and application of the BioBA Solution for pre-clinical and clinical biologics quantitation. Ian is a graduate of the University of Toronto and holds a PhD in organic chemistry.

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