Basis of Interactions in Gas Chromatography, Part 1 – Non-Polar Interactions

Understanding the fundamental intermolecular interactions that lead to retention, mainly dispersive, non-polar interactions is discussed.

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byMatthew Klee

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To fully grasp the concepts of retention and selectivity of GC stationary phases, one must first understand the fundamental intermolecular interactions that lead to retention. This article discusses the most dominant of those interactions – dispersive, non-polar interactions.

There are fewer types of intermolecular interactions available for interactions between solutes and stationary phases in gas chromatography compared to those possible in liquid chromatography. In addition, the mobile phase in GC (the carrier gas) plays no role in adjusting or modifying the nature of intermolecular interactions during the run. So, the range of possibilities in retention forces and selectivity is much more limited in GC than in LC.

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Meet the Author(s):

Matthew Klee
Dr Matthew S. Klee is internationally recognized for contributions to the theory and practice of gas chromatography. His experience in chemical, pharmaceutical and instrument companies spans over 30 years. During this time, Dr Klee’s work has focused on elucidation and practical demonstration of the many processes involved with GC analysis, with the ultimate goal of improving the ease of use of GC systems, ruggedness of methods and overall quality of results.

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