Qualitative - Quantitative - General Unknown - A SWATH® based All-in-One Workflow in Forensic Toxicology?
presented by Michael Potzsch
The market for illegal and controlled substances is subject to fast and dynamic changes - their detection requires fast and flexible analytical methods especially with reference material often not available. This webinar offers an insight into the opportunities and pitfalls during method development and applications of SWATH DIA HRMS methods in forensic toxicology.
Extraction of Illicit Drugs and Pesticides from Liver Tissue Prior to GC-MS Analysis
This application note describes an effective and efficient ISOLUTE SLE+ protocol optimized for the 1 mL capacity column format. The simple sample preparation procedure delivers clean extracts, good recoveries and RSD values and LLOQ of 50 ppb, suitable for screening applications. A protocol has been developed that allows the simultaneous extraction of various drugs of abuse classes: amphetamines, barbiturates, benzodiazepines, cocaine, ketamine, THC.
Analysis of Tryptic Digests of a mAb and an ADC
Monoclonal antibodies have emerged as important therapeutics for the treatment of cancer and autoimmune diseases. The successes of mAbs have triggered the development of various next-generation formats ADCs, which enable highly toxic drugs to be selectively delivered to tumor cells.