At ASMS 2026, Bruker Corporation announced several mass spectrometry innovations, introducing new instruments, software, and partnerships to advance 4D proteomics, functional proteoform analysis, 4D metabolomics, energy industry research, and semiconductor manufacturing.
Ultra-High-Resolution and Energy Industry Solutions
Bruker launched the timsMRMS mass spectrometer, which combines trapped ion mobility separation with magnetic resonance mass spectrometry (MRMS). The system delivers a mass resolving power of 1M to 10M, ppb mass accuracy, and a single-acquisition dynamic range spanning four orders of magnitude. This technology targets complex mixture analysis in petroleomics, dissolved organic matter, biofuel fingerprinting, and battery research.
For the semiconductor industry, Bruker introduced TOFWERK airborne molecular contaminant (AMC) TOF-MS solutions to optimize yield, securing a multi-million-dollar order from a leading global memory manufacturer.
High-Throughput Proteomics and Oncology Applications
Updates to the timsUltra AIP system, razor-PASEF methods, and Spectronaut 21 software now enable the identification and quantification of more than 10,000 proteins in cell lines and tissue, and over 6,500 proteins at 500 samples per day (SPD). A translational oncology initiative by Prof. Stephan Singer at University Hospital Tübingen and Prof. Oliver Schilling at University of Freiburg utilizes this technology on formalin-fixed paraffin-embedded (FFPE) tissue biopsy samples. Stephan Singer commented: "In complex cancer cases, genomics does not always provide decision-relevant answers, particularly with FFPE tissue. With timsTOF-based proteomics we routinely quantify more than 10,000 proteins across clinical samples, adding functional pathway activity, metabolic dependencies, and tumor-specific resistance programs. This can enable proteomics-driven therapy strategies exploiting signaling vulnerabilities and metabolic reprogramming, or new target discovery, where NGS remained inconclusive."
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Advanced Proteoform Characterization
The timsOmni platform features an Argon collision gas option that improves collision-induced dissociation (CID) sensitivity for biomolecules by 4x. Bruker also partnered with Integrated Protein Technologies (IPT) to interface the SampleStream system with the timsOmni under HyStar control. This setup automates buffer exchange using a molecular-weight-cutoff membrane, delivering mass spectrometry-ready samples in under two minutes per sample.
On the software side, Bruker introduced OmniScape 2027, ProteoScape 2027, and GlycoScape 2027. OmniScape 2027 contains LYRA, a de novo algorithm for PTM screening and protein sequence annotation. The update also features tims-Casanovo, a transformer neural network developed in collaboration with the University of Washington, Helmholtz Munich, and the University of Antwerp to translate MS/MS spectral peaks into amino acid sequences.
Hybrid Metabolomics and Air Exposomics
Bruker expanded its metabolomics portfolio by integrating MetaboScape with ecTOF dual ionization for simultaneous electron ionization (EI) and chemical ionization (CI) processing. Additionally, the company initiated a key early-access program on the timsMetabo platform. Dr. Michael Witting, Helmholtz Munich, noted: "Metabolomics research demands both quantitative data and broad exploratory coverage, but combining these has meant separate workflows, adding complexity. Bringing targeted and untargeted metabolomics together in a single experiment simplifies large-scale studies for a more complete picture of metabolic changes driving disease."
Following its January 2026 acquisition of TOFWERK, Bruker launched an Air Exposomics initiative combining real-time volatile organic compound (VOC) monitoring and trace-metal aerosol analyzers with 4D metabolomics and lipidomics.
