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Building Robust LC-MS and GC-MS Workflows for Real-World Samples

A workflow-level approach to robustness helps laboratories maintain long-term LC-MS and GC-MS performance when analyzing complex food and environmental samples.
Written bySeparation Science
InterviewingTarun Anumol

Analytical laboratories working in food and environmental testing rarely handle pristine samples. Instead, they analyze complex, variable matrices that place sustained demands on both instruments and workflows. According to Tarun Anumol, Director of Global Applied Markets at Agilent Technologies, robustness must be defined around real-world samples rather than idealized conditions.

Agilent’s approach to robustness builds on long-standing design improvements across GC-MS and LC-MS platforms, including advances in quadrupoles, ion optics, and electronics that support stable, long-term operation with challenging matrices. These developments help laboratories maintain consistent performance and data quality over extended use.

However, instrument design alone does not solve robustness challenges. Sample preparation, front-end handling, and data processing all influence system durability and uptime. By working closely with customers, Agilent takes a workflow-level view—addressing analytical challenges holistically rather than as isolated instrument issues.

For laboratories managing demanding applications, robustness emerges from aligning technology, workflow, and real sample needs.

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Interviewing

  • Tarun Anumol

    Tarun Anumol is currently the Director for the Global Applied Markets at Agilent Technologies, where he is responsible for a team that identifies key trends in the environmental, food, materials, chemical, and energy testing markets to address unmet customer needs. He has previously served as market manager for the food and environmental markets, focussed on developing strategies to address testing needs. Prior to this, he was an LC-MS applications scientist at Agilent, focused on developing analytical methods for trace contaminants like PFAS, hormones, drugs, and algal toxins on LC-MS/MS and LC-Q/TOF in food and environmental matrices. Tarun has a strong history of working in the environmental testing industry, with a background in technical and applied science, with over 30 peer-reviewed journal publications in this area. He currently serves on the executive committee of the Environmental Sciences Section for the American Council of Independent Laboratories (ACIL), the chair of the Industrial Outreach Committee for the American Chemical Society (ACS), and on the Steering committee for the National Environmental Monitoring Conference (NEMC). 

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