Liquid Chromatography

A hand dipping naan into a sauce, representing food allergen testing challenges.
Articles
This article examines the analytical challenges posed by new allergens—such as lupin, fenugreek, and insect protein—and suggests strategies for laboratories to adjust their ELISA and LC-MS/MS methods ahead of new regulations.
Articles
How high-resolution mass spectrometry and multiclass extraction strategies reveal the fate of unregulated organic contaminants in biosolids and agricultural soils.
Articles
A practical LC–MS/MS workflow addresses the challenge of measuring 6PPD-quinone and related tire-derived contaminants in high-fat salmon tissue at environmentally relevant levels.
Articles
Smaller-scale LC, microflow MS, and reduced-volume sample prep are key Scope 3 decarbonization strategies for separation scientists, with significant climate impact across pharma, biotech, and food testing labs.
Purple and blue cells and molecules
eBooks

Complete Workflow Solutions for Therapeutic Peptides and GLP-1 Agonists

A digital illustration of oligonucleotides flowing through a futuristic chromatography column, where a glowing blue energy field representing controlled retention factor actively organizes chaotic, tangled strands into distinct, resolved bands, symbolizing the separation of impurities.
Articles

Executive Summary: Controlling Retention Factor in Oligonucleotide Chromatography

Blocks showing the year 2025 in analytical science
Articles

Analytical Science in 2025: Steady Progress Through Refinement

3D rendering illustrating mass transfer kinetics in a core-shell column. GLP-1 peptide ribbons (blue/green) interact with the porous shell stationary phase but are blocked by the solid silica core, minimizing the Van Deemter C-term contribution.
Articles

Core-Shell Particle Technology for Peptide Work: Mechanisms for Improving Resolution in GLP-1 Analysis

Analytical chemists in a laboratory troubleshoot a GLP-1 peptide method, analyzing chromatogram data for retention drift or peak distortion next to a UHPLC instrument.
Articles

Troubleshooting GLP-1 Agonist Methods: Real Failures, Root Causes, and Fixes in UHPLC/HPLC

Complex peptide-like molecular structures representing large drug metabolites analyzed by LC-MS/MS
Learning Hubs

Build Confidence in Metabolite Identification

A modern analytical laboratory outfitted with a high-performance liquid chromatography (HPLC) system and computer data station, used by chromatographers to identify instrument issues like downward baseline drift during gradient HPLC runs.
Articles

Downward UV Baseline Drift During Gradient HPLC: What %B Can Reveal

A conceptual illustration showing a mass spectrometer instrument analyzing glowing exosomes flowing through a microfluidic channel. A screen in the background displays data charts, graphs, and chemical structures, illustrating the process of exosome proteomics and metabolomics profiling.
Articles

Proteomic and Metabolomic Profiling of Exosomes for Biomarker Discovery

Dropping chemical liquid to test tube, laboratory research and development concept.
Webinars

Fast Wins: Preparative LC Tips for Beginners Ready to Use Tomorrow

(+ 1 Broadcast)
DNA and RNA concept on purple background
Webinars

A Masterclass in Advanced Analytical Assays for Bioanalysis of Oligonucleotides

Available on Demand