Liquid Chromatography

Dynamic blue light streaks radiate from a bright central point, symbolizing speed and precision, representing the concept of ultra-fast mass spectrometry in modern analytical science.

Thought Leadership

Ultra-Fast Mass Spectrometry Transforms Analytical Workflows

byAimee Cichocki andLandon West

| 3 min read

UFMS boosts throughput and precision across clinical, environmental, and food testing workflows.

Sample Prep Strategies for Multi-Class Drug Analysis in Whole Blood

Explore a comparative study of solid-phase extraction, supported liquid extraction, and other protein and phospholipids removal extraction techniques.

Modernize Your Approach to Multi-Residue Pesticide Analysis

byWaters andRestek

A strategic guide to improving sample prep, detection, and screening in high-volume labs

Reverse Phase vs Normal Phase HPLC: How to Choose the Right Tool

| 3 min read

When resolution counts, choosing the right phase can make or break your method. Here's what lab veterans say.

Compact Capillary Liquid Chromatography: Advances and Applications

bySeparation Science andAxcend

Available On-Demand

The image shows pharmaceutical capsules representing stability testing in drug development. It emphasizes analytical techniques critical for evaluating drug stability, shelf-life determination, and maintaining pharmaceutical quality standards.

Analytical Techniques In Stability Testing

| 5 min read

Pittcon 2025: Analytical Innovations from Industry Leaders

byAimee Cichocki

| 4 min read

Automated Sample Preparation for Multi-Residue Pesticide Analysis by LC-MS and GC-MS

byBiotage andSeparation Science

Available On-Demand

Enhancing PFAS Analysis in Food Testing with 2D-LC/MS | Beyond the Bench

byAimee Cichocki, Susanne Soelter, andStephan Buckenmaier

| 4 min read

Non-Targeted Analysis Reveals PFAS Gaps | Beyond the Bench

byAdam Dickie andJonathan Spencer

| 4 min read

This image of glowing UV lamps illustrates the role of ultraviolet absorbance in HPLC peak purity analysis. PDA detectors measure spectral variations to determine whether a peak represents a single compound or contains coeluting impurities. Understanding how UV-based detection works is essential for accurate impurity profiling and method validation in chromatography.

Peak Purity in HPLC: Assessment, Troubleshooting, and Best Practices

| 3 min read

Optimizing Pharma and Biopharma Analysis Workflows

byAgilent andSeparation Science

This image illustrates the abstract nature of molecular separation and analysis, reflecting the complexity of processes such as SEC and AEX in gene therapy analytics.

Size Meets Charge: Chromatography Techniques for AAV Analysis

| 4 min read

A vibrant green landscape filled with various icons and symbols representing sustainable chromatography practices.

Sustainable Chromatography: Embracing Software for Greener Method Development

| 7 min read

A futuristic graphic showcasing advancements in separation science illuminates the years 2024 and 2025 with glowing arrows and digital elements, all enveloped in a sleek blue and purple color scheme.

Separation Science in 2024: A Year of Insights and Innovation

byAimee Cichocki

| 5 min read

Application Notes

Maximizing Sample Throughput and Sensitivity in Nano- and Capillary-LC-MS

byThermo Fisher Scientific andSeparation Science

A detailed 3D illustration of the AAV capsid, a critical component of adeno-associated viruses used in gene therapy. The image emphasizes the capsid's role in protecting and delivering the therapeutic DNA, a key focus of analytical chemistry in AAV characterization.

AAVs Explained: Structure, Safety, and Analytical Chemistry

| 4 min read

This image highlights the integration of lab automation and chromatography consumables, with a technician scanning vials to ensure precision, efficiency, and seamless workflows in analytical chemistry labs. The action underscores advancements in smart consumables and their role in improving lab productivity.

Chromatography 2025: Redefining Consumables

| 4 min read

Green Chromatography: Reducing Environmental Impact in Lab Practices

byAimee Cichocki andGiorgia Greco

| 3 min read

This image depicts rows of pharmaceutical vials in a manufacturing setting, representing the role of Quality by Design (QbD) in HPLC method development. It highlights how QbD ensures consistent quality, regulatory compliance, and robust analytical methods in pharmaceutical processes, making it ideal for beginners in GMP environments.

A Beginner’s Guide to Quality by Design (QbD) for HPLC Method Development

| 5 min read

Tackling Scope 3 Emissions: The Role of Analytical Scientists in Greening Labs

byAimee Cichocki andJames Connelly

| 4 min read

Chiral Separation Method Development for Warfarin Enantiomers

byKamran Falahatpisheh andAtis Chakrabarti

| 7 min read

C8 vs C18 Column: Which Should You Choose?

byAimee Cichocki

| 3 min read

This image depicts a cutting-edge laboratory equipped with advanced technology, reflecting the article's focus on innovations in chromatography, such as AI-driven automation, high-throughput systems, and sustainable practices transforming the field by 2025.

Chromatography 2025: The Trends Transforming Laboratories

| 4 min read

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