Checking procedures for hydrogen or nitrogen transition

transition-to-hydrogen-or-nitrogen

How to evaluate hydrogen and nitrogen as alternatives to helium, with practical guidance on performance, safety, and method revalidation.

Switching Carrier Gases in GC and GC&ndash;MS: What Labs Need to Know

Articles

Methylmalonic acid testing materials including syringes and capsules.

methylmalonic-acid-detection

LC&ndash;MS/MS expert Bryan Tackett explains how supported liquid extraction and polar-embedded chromatography improve the accuracy and reliability of methylmalonic acid quantification in serum.

Precision in Vitamin B12 Assessment: Optimized LC&ndash;MS/MS Method Enhances Methylmalonic Acid Detection

Helium's position in the periodic table, relevant to GC-MS discussions

helium-shortage-impact-on-gc-ms

Helium shortages push labs to rethink carrier gas strategy. Hydrogen and nitrogen offer viable paths, but each demands careful method optimization and safety planning.

Rethinking Carrier Gases in GC and GC&ndash;MS: Moving Beyond Helium

Detailed view of an inert GC column used in analytical chemistry

gc-column-inertness

GC column inertness enhances performance, reducing bleed to improve sensitivity for challenging analytes. Discover the benefits today!

Why GC Column Inertness Still Shapes Difficult GC Analyses

Assorted colorful pharmaceutical pills and capsules on a white surface, representing the expanding pipeline of accessible therapeutics driven by Next-Generation Biosimilar Development.

next-generation-biosimilar-development

A deep dive into the FDA&rsquo;s evolving 2025 and 2026 draft guidances, which pivot biosimilar approval away from traditional clinical efficacy trials and heavily toward high-resolution analytical comparability and targeted pharmacokinetic studies.

Next-Generation Biosimilarity: Leveraging Advanced Analytical Techniques and PK Data to Meet New FDA Guidance

Molecular structure representation for GLP-1 receptor agonists

glp-1-receptor-agonists

eBook cover on analytical workflows for GLP-1 receptor agonists

glp-1-ebook-thumb

Agilent

Explore robust analytical workflows for GLP-1 receptor agonists, ensuring reliability in peptide characterization and purification.

Streamlined Analytical Workflows for GLP-1 Receptor Agonists

eBooks

3D molecular structure representing peptide engineering for GLP-1 therapeutics

peptide-engineering-for-therapeutics

Characterizing complex GLP‑1 and dual‑agonist therapies requires advanced orthogonal separations and high‑resolution mass spectrometry.

The Analytical Separation Engine Driving the Next Generation of GLP‑1 Therapeutics

 MaxPeak Premier Solutions Small Molecule Pharmaceutical Application Notebook cover

waters-small-molecule-app-notebook-415920

Abstract molecules on water background as a 3D illustration

waters-small-molecule-app-notebook-415920-hero

Waters

Learn how reducing metal surface adsorption can improve sensitivity, consistency, and reliability in analytical workflows for challenging compounds.

Small Molecule Pharmaceutical Applications: Overcoming Adsorption for Reliable Results

Chemist analyzing data in a lab with HPLC equipment

hplc-retention-time-shifts

A Chromatography Forum case reveals why identical HPLC methods can produce drastically different retention times across systems, and how to diagnose and correct the issue.

HPLC Method Transfer: Why Retention Times Shift Between Systems, and How to Fix It

sciex-on-demand-1-mrna-dec25-hero

Cover for mRNA therapeutics executive overview

sciex-exec-overview-mrna-cover

SCIEX

Build a tissue-resilient assay using a step-by-step framework for peptide selection and digestion control.

Liquid Chromatography

Switching Carrier Gases in GC and GC–MS: What Labs Need to Know

Precision in Vitamin B12 Assessment: Optimized LC–MS/MS Method Enhances Methylmalonic Acid Detection

Rethinking Carrier Gases in GC and GC–MS: Moving Beyond Helium