Complex wastewater and biosolids are exposing the limits of traditional PFAS testing: as regulatory thresholds drop, external calibration leaves measurements highly vulnerable to matrix-driven effects. While EPA Method 1633 solves this vulnerability by mandating isotope dilution, applying the protocol to high-moisture samples reveals severe sample preparation bottlenecks.
In this executive summary of a recent SCIEX webinar, Dr. Sarah Choyke, Technical Director at Eurofins Environment Testing, shares laboratory data demonstrating how sludge moisture and total suspended solids dictate whether target recoveries fall within acceptable validation limits.
Download this executive summary to learn:
- How isotope dilution corrects the extraction losses that drop external-standard recoveries of perfluorobutanoic acid to zero
- Why centrifuging wastewater to protect solid-phase extraction cartridges discards particle-bound long-chain sulfonamides
- Which thermal destruction steps leave only short-chain perfluoropropanoic acid in the final ash once longer-chain sulfonic acids are destroyed
