Webinars

From Raw Materials to Conjugation Sites: Advanced LC, MS and MALS Strategies for AOC Characterization

Available on Demand

Explore advanced analytics for next‑generation protein therapeutics.

Event Overview

Proteins like monoclonal antibodies (mAbs) and protein conjugates promise higher efficacy and novel targets compared to traditional therapies. Given their biotherapeutic structural complexity, these molecules pose significant analytical challenges, with quality attributes like composition, aggregation, purity, and conformation affecting efficacy and toxicity.

This webinar explores the comprehensive analysis of Antibody Oligonucleotide Conjugates (AOCs) using Liquid Chromatography-Mass Spectrometry (LC-MS) and Liquid Chromatography-Multi-Angle Light Scattering (LC-MALS).

By viewing this presentation you will:

Discover methodologies for accurate pairing of technology and attribute across the product lifecycle
Learn about recent advances, with insights into adopting advanced analytics
Ensure novel and robust analytical capability for the analysis of bioconjugates

Who should attend?

This webinar is designed for you if you are a scientist, lab manager, director, or analyst involved in protein development, process development, or quality control of AOCs, ADCs, or other protein therapeutics.

Bonus Content

Expanding the Antibody-Oligo Conjugate(AOC) Characterization Toolbox 3 Parts

Application Notes
Expanding the Antibody-Oligo Conjugate (AOC) Characterization Toolbox: Parts 1–3

WP8010-Determination-of-Multiple-Quality-Attributes-of-AOC-with-SEC-MALS-and-AEX-MALS

White Paper
Determination of Multiple Quality Attributes of Antibody-Oligonucleotide Conjugate with SEC-MALS and AEX-MALS

Speakers

Samantha Ippoliti
Principal Scientist, Biologics Business, Waters Corporation
Samantha (Sam) joined Waters (Milford, MA) in 2018 and has worked on a variety of applications for LC-MS based biopharmaceutical characterization, including peptide mapping & intact/subunit analysis, and most recently antibody-oligonucleotide conjugates (AOCs).
Sam has experience with LC-MS analysis using BioAccord, Xevo series, Synapt XS, and Cyclic IMS LC-MS instruments.
Prior to joining Waters, she was part of the LC-MS characterization group supporting a biopharmaceutical developability assessment group at Novartis in Cambridge, MA. Sam acquired a BS-MS in Chemistry from Northeastern University in 2012.
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Nick Pittman
Global Marketing Manager, Biologics Business, Waters Corporation
Nick Pittman brings over two decades of expertise in mass spectrometry and liquid chromatography, with a strong focus on applying Waters’ analytical technologies to biopharmaceutical research and development. Over 13 years at Waters, he has held technical and business roles that deepen his understanding of both the science and strategy behind analytical solutions. Before joining Waters, Nick spent 10 years at Pfizer UK, specializing in LC and LC‑MS techniques to support drug development.
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