Overview
Per- and polyfluoroalkyl substances (PFAS) are now known to be ubiquitous, being detected in several matrices including water, air, soil, animals, commercial products and even in humans.
Yet, only a handful of PFAS have been monitored in detail globally while even fewer have had toxicological evaluations performed on them. With >6,000 estimated to have been commercially produced, the need for robust and reliable testing & analysis of these compounds is critical. This on-demand symposium, produced in collaboration with Agilent, comprises presentations from experts in the field of PFAS analysis covering a wide variety of topics to improve PFAS testing for widescale monitoring and improved data quality in a number of different matrices.
Additional On-demand Content
Why Register?
Learn about: the latest advances in quantification of legacy and novel PFAS; developing and accreditation for routine and regulatory PFAS methods including EPA and EU guidelines; novel analytical techniques to identify new PFAS; and testing methods optimized for water, air, commercial products, textiles, soil and others.
Optimizing Water, Soil, and Serum Sample Extraction for PFAS analysis
Dr. Bradley Clarke (Senior Lecturer in Environmental Science and Analytical Chemistry, University of Melbourne, Australia)
The quantification of PFAS from environmental samples is a complicated undertaking due to the high levels of contamination typically observed in most laboratories. Sample preparation and extraction are critical aspects of any workflow for PFAS analysis and demands a serious level of attention, like the LCMS operation. In this talk, I will provide an overview of the sample extraction processes for the extraction of PFAS from water, soil, and serum, including steps taken to reduce sample volume without sacrificing limits of quantification. By watching this presentation you will learn about:
- Common techniques used for water analysis using solid-phase extraction (SPE).
- Approaches for minimising sample volume and use of costly internal standards.
- Workflows for the quick extraction of PFAS from solid matrices.
Optimization and Application of Analytical Methods for Assessing PFAS Treatment and Toxicity
Dr. Arjun Venkatesan (Associate Director, Center for Clean Water Technology, Stony Brook University, USA)
PFAS are highly persistent and resistant to degradation and have been associated with reproductive toxicity, reduced growth metrics in newborns and elevated cholesterol levels in humans. Currently, there are no federal regulations for PFAS in drinking water and as a result many U.S. states have their own regulation or health advisory levels. Our laboratory at the New York State Center for Clean Water Technology (CCWT) has established a certified PFAS testing facility to support ongoing research focused on their occurrence, fate, treatment, and toxicity. This presentation will summarize our experience in developing various EPA methods for PFAS analysis and highlight some method modifications developed for specific applications. By watching this presentation you will learn:
- How do different EPA methods perform for PFAS quantification?
- What are some challenges in the application of EPA methods for PFAS research?
PFAS Analysis: Application in the Water Works of Berlin, Germany
Frederik Zietzschmann (Laboratory of Berliner Wasserbetriebe, Germany)
PFAS are an abundant class of legacy and current contaminants in the catchments of many water works around the world. In Berlin, Germany, PFAS are monitored extensively due to the prospective strict regulatory measures from the European Union and German environmental authorities. With required limits of quantification in the very low ng/L range, sensitive techniques are applied and potential improvements are explored. These analytical means are complemented by research activities regarding PFAS analysis, sampling, and removal, as well as contributions to national and international standardization. By watching this presentation you will learn that:
- Thorough monitoring of PFAS will be required by many water works due to strict regulatory limits
- Analytical sensitivity must be further increased to satisfy the required limits of quantification
- Technologies for PFAS removal must be improved to comply with limit values
Perspectives and Challenges of Commercial Environmental PFAS Testing in the USA
Stephen Somerville (Technical Director – PFAS, Pace Analytical, USA)
As regulatory action on PFAS contamination and exposure expands globally, contract labs providing the necessary analyses face a challenging technical and business environment. Within the USA, there are very few standardized methods covering what are a wide variety of environmental and commercial matrices, with refinements and new methods rapidly being introduced to expand applicability and improve resultant data. New client investigations – driven by current, proposed, or expected regulations – drive technical innovation and lead to new commercial opportunities for contract labs. Maintaining a focus on technical quality and compliance while managing a wide range of applications and expectations, Pace strives to provide a portfolio of valuable product offerings to a rapidly evolving marketplace. By watching this presentation you will learn about:
- Overview of the rapidly evolving landscape of standardized PFAS test methods.
- Challenges in a commercial (i.e., production) laboratory, and how operational and technical systems are implemented to overcome them.
Novel Analytical Tools for Per- and Poly-fluoroalkyl Compounds and ISO21675
Dr. Nobuyoshi Yamashita (Chief Senior Research Scientist at the Research Institute for Environmental Management, National Institute of Advanced Industrial Science and Technology [AIST], Japan)
Development of ISO21675, the most recent International Standard Method for PFAS in water is described. Then, novel analytical tools for volatile/neutral PFAS in air and water are discussed. A brand-new technology, simultaneous analysis of neutral and ionizable per- and polyfluoroalkyl substances in air is firstly reported in front of audience. This research tool enables the next generation of mass balance analysis of all PFAS in the environment, namely more than five thousand chemicals. Heart of lecture is “how important QAQC for PFAS analysis”. Sensitivity of "1 pg/L" with 10%RSD and "1 ng/L" with 50%RSD are completely different world. Which do you choose? By watching this presentation you will learn about:
- The history and advantage of ISO21675
- Simultaneous analysis of neutral and ionizable per- and polyfluoroalkyl substances in air
- Quality assurance and quality control of solid phase extraction for PFAS in water and novel analytical techniques for PFAS analysis
Uncovering Xenobiotics in Nontargeted Analyses using Ion Mobility Spectrometry, Mass Defect Analysis and Machine Learning
Erin S. Baker, Ph.D (Associate Professor, North Carolina State University, USA)
The identification of xenobiotics in nontargeted analyses is a vital step in understanding human exposure. Xenobiotic metabolism, excretion, and co-existence with other endogenous molecules however greatly complicates nontargeted studies. This presentation will demonstrate how combining mass defect analysis, machine learning and liquid chromatography, ion mobility spectrometry and mass spectrometry (LC-IMS-MS) separations enables an in-depth understanding of molecular responses occurring due to chemical exposures. By watching this presentation you will learn about:
- The power of multidimensional LC-IMS-MS platforms for nontargeted analyses.
- The utility of multidimensional libraries for narrowing down potential feature identifications.
- LC-IMS-MS capabilities for improving the detection, identification and validation of endogenous and xenobiotic features.
Latest Regulations & Standards on PFAS Testing in the Materials Industry
Dr Yuhong Chen (Global Materials Segment, Applied Markets, Agilent Technologies)
Sampling and Analysis of Volatile PFAS in Air by TD-GC-MS
Carlos Gil (Business Development Manager, Markes International GmbH)
Streamlined PFAS Annotation and Visualization with FluoroMatch Flow and Visualizer
Stephen Baumann (Application Applied Segment Manager, Agilent Technologies)
Using Thermal Desorption and GC-MS/MS for the Analysis of PFAS Compounds in Air for Improved Detectability & Reliability
Kurt Thaxton (Gerstel)
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