This technical article discusses the process of hot split injections and the sources of discrimination, which are one of the potential downsides of this technique.
Our discussion continues about the process of hot split injection; the most popular form of sample introduction into capillary columns. One of the reasons that a split inlet is so useful is because it is so flexible. It accommodates a wide range of sample concentrations, solvent types, and injection volumes. It also works with almost any size of capillary column. However there are ways that you can get into trouble if you are not careful.
The following are potential downsides of any hot sample introduction technique:
- Discrimination
- Decomposition
- Overload
Let’s cover one of them in more detail.
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