A modified workflow based on EPA Method 1633A was applied for the analysis of 40 per- and Polyfluoroalkyl Substances (PFAS) in a range of solvents. Solid-phase extraction (SPE) combined with LC-MS/MS was used to assess the PFAS background of 19 solvent products, including water, acetonitrile, and methanol of different grades. Ensuring solvent purity was identified as essential for achieving reliable PFAS measurements and for preventing false positives or overestimation of PFAS concentrations.
Download this application note to:
- Understand how a modified EPA Method 1633A can be used to detect PFAS in common laboratory solvents.
- Recognize the importance of solvent purity in preventing false positives and ensuring accurate PFAS measurements.
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