In this Issue

Abstract visualization of analytical technology forming a protective barrier between harmful molecules and safe food.

Next-Gen Quantitation: Advancements in Mycotoxin and Alkaloid Analysis for Enhanced Food Safety

Holly Lee discusses how advanced mass spectrometry and ultrafast multiple reaction monitoring workflows are tackling the analysis of mycotoxins and achieving ultra-trace level quantitation to meet stringent global food safety regulations.
Abstract 3D molecular structure with colored particle dispersion, representing fragmentation-first tandem MS and neutral-loss fragmentation in high-throughput reaction screening.

Fragmentation-First Tandem MS: Redesigning High-Throughput Reaction Screening in Drug Discovery

By tracking how starting materials fragment, reactions are ranked at scale, without chromatography.
3D molecular model depicting biopharma innovation in drug development

A New Era of Biopharma Innovation: Analytical Instrumentation Required

Explore how biopharma innovation drives resurgence in drug development, improving patient care with advanced technologies.
Microflow LC-MS technology illustrated with test tubes and DNA strand

Microflow LC-MS: Sensitivity, Stability, and Scalability

Explore how microflow LC-MS revolutionizes proteomics with enhanced sensitivity and robustness for scalable workflows.
A 3D scientific visualization of an array of multi-ring estrogen molecules, related to the optimized LC-MSMS method for estrogens described in the article. Specific functional groups are highlighted with a glowing green signal. Diagonal green lines connect these glowing areas, emphasizing the distinct molecular regions critical for streamlined, high-sensitivity separation without derivatization.

Advancing Estrogen Quantitation: Achieving Sub-10 pg/mL Sensitivity Without Derivatization

Stephanie Marin explains a breakthrough workflow that uses specialized biphenyl chromatography and novel mobile-phase chemistry to quantify estrone and estradiol at picogram levels, thereby eliminating the need for complex derivatization. 
Visual representation of compound semiconductor fabrication with layered designs.

Why Separation Science is the New Gatekeeper of Semiconductor R&D

By leveraging inline separation columns, kinetic cleaning, and AI-driven drift detection, photonic engineers are pushing analytical limits from ppb to ppt to safeguard the next generation of 6G devices.
Close-up of a crop sprayer boom applying a fine mist of agricultural treatments to a green field at sunset, representing the real-world residues analyzed by the QECh*All mega-method for food safety monitoring.

Beyond QuEChERS: The QECh*All Mega-Method and the Future of Residue Analysis

Steven Lehotay explains how modernizing sample prep and adopting high-throughput workflows can revolutionize food safety monitoring.