Cover of Separation Science September 2025 issue titled “Smarter Science: Aligning Data, Devices, and Decisions,” highlighting portable LC for jet fuel testing, vaccine quality control methods, and the impact of data, AI, and automation on analytical labs.

September 2025 | Issue 7

Smarter Science: Aligning Data, Devices, and Decisions

In this Issue

Top view of foods rich in vitamin D, including salmon, eggs, cheese, mushrooms, milk, and supplements, arranged around a wooden board with the letter "D"—ideal for illustrating a concept related to vitamin D analysis in nutrition and food science.

Unlocking the Power of Vitamin D: How Automated Mass Spectrometry is Streamlining Testing

Mass spectrometry addresses the growing need for accurate vitamin D metabolite testing globally.
Close-up of a mineral matrix with sharp-edged crystals, illustrating the type of complex solid sample that can be analyzed using dual-laser mass spectrometry.

A Simpler Path to Solid Sample Analysis with Dual-Laser Mass Spectrometry

Solid sample analysis is entering a new era—no digestion, no gas, just rapid, reproducible elemental results across complex matrices.
First responders in protective gear clean up an oil spill; future approaches like hydrophobic paper sampling aim to simplify field collection in such conditions.

Q&A with Dr. Dayue Shang: Rethinking Oil Spill Analysis Through Hydrophobic Paper Sampling and Faster Detection

Dr. Dayue Shang discusses how hydrophobic paper sampling with DART-ToF MS offers faster, simpler oil spill analysis, reducing costs and enabling broader field use.
3D rendering of tangled blue protein structures on a black background, representing formations observed during protein aggregates analysis.

Protein Aggregates: Analytical Techniques to Address Hidden Complexities

Protein aggregates analysis is critical to drug stability. Advanced SEC methods offer precise detection and quantification to support biopharmaceutical development.
Spraying equipment applies herbicides across a crop field, representing a key stage in agricultural practices relevant to herbicides analysis.

Building Improved Workflows for Herbicide Discovery: A Case Study with Moa Technology | Beyond the Bench

Moa Technology adopts a high-resolution LC/MS strategy, combining high-throughput screening and targeted metabolomics.
Two military fighter jets flying above the clouds during a mission related to jet fuel testing, showcasing real-time aerial analysis capabilities.

Portable LC Redefines Jet Fuel Testing for On-Site MDA Detection

A portable LC system brings real-time MDA detection to the field, enabling faster jet fuel testing and supporting efforts toward ASTM standardization.
Futuristic user interface concept illustrating biomarker analysis with a holographic human figure, digital diagnostics icons, and molecular structures in a high-tech medical visualization.

Expert Q&A: Biomarker Analysis in the Modern Lab

Discover how Dr. Jean-François Focant's lab is advancing biomarker analysis through rigorous validation protocols and innovative identification strategies.
Aerial image of wildfire damage in the La Viña community near Los Angeles, highlighting the extent of structural loss and the importance of VOC monitoring with SIFT-MS in post-fire environments.

LA Wildfire Contamination: Monitoring VOCs in Real Time with SIFT-MS

Following the 2025 LA wildfires, SIFT-MS was used to monitor VOC contamination in homes, insulation, and soil. Explore key findings, exposure insights, and the importance of real-time VOC analysis in post-fire environments.
Scientist using a digital tablet and stylus in a high-tech lab environment with data visualizations and interface graphics overlayed, representing innovations in analytical science.

Reshaping Analytical Science: Data, AI, and Mindset Shifts

Emerging technologies demand new ways of thinking about data, automation, and sustainability across the analytical sciences.
Digital visualization of laboratory vials with overlaid data charts, DNA strands, and human health graphics, symbolizing the integration of LIMS (LaboraDigital visualization of laboratory vials with overlaid data charts, DNA strands, and human health graphics, symbolizing the integration of LIMS (Laboratory Information Management Systems) in modern analytical workflows.tory Information Management Systems) in modern analytical workflows.

5 Key Trends Shaping the Future of LIMS

Modern LIMS platforms are evolving rapidly—adopting cloud, AI, and user-centric design to meet the demands of today’s digital labs.
Sliced seitan, a plant-based protein source, displayed with spices, representing food samples analyzed using ICP-MS for trace metal testing in alternative proteins.

Expert Q&A: Unlocking the Role of ICP-MS in Alternative Protein Testing

Yuri Tanaka, Product Marketing Manager at Agilent Technologies, examines how ICP-MS enables the analysis of trace metals in alternative proteins, addressing regulatory challenges, complex matrices, and workflow integration.
Vaccine vials and a syringe on a clean laboratory surface, representing the final stage of vaccine production and the importance of vaccine quality control.

Expert Q&A: Vaccine Quality Control in Analytical Methods and Emerging Technologies

Dr Arnaud Delobel of Quality Assistance discusses vaccine QC strategies, from platform-specific analytical methods to validation challenges, emerging technologies, and regulatory considerations.
Close-up macro science bubbles

Expert Q&A: Why Supported Liquid Extraction Beats SPE for Clinical LC-MS/MS

As mass spec sensitivity rises, learn how labs are replacing complex SPE steps with high-performing supported liquid extraction (SLE).