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Method Adjustment vs Change Part 1: Overview

This Edition of HPLC solutions is looking at the overview of the concept of method adjustment vs method change in reversed-phase HPLC
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Written byJohn Dolan
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In the first part of this series, an overview of the concept of method adjustment vs method change in reversed-phase HPLC is presented.

We all know that no HPLC method is perfect and that it may need to be “tweaked” once in a while to make it operate properly. But in today’s highly regulated environment, there’s always a question about whether or not such adjustments are allowed. For compendial methods in the pharmaceutical industry, the various pharmacopoeia give guidelines about method adjustment.

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Meet the Author(s):

  • John Dolan

    John Dolan

    John Dolan is considered to be one of the world’s top experts in HPLC. He has written more than 300 user-oriented articles on HPLC troubleshooting over the last 30 years, in addition to more than 100 peer-reviewed technical articles on HPLC and related techniques. His three books (co-authored with Lloyd Snyder), Troubleshooting HPLC Systems, Introduction to Modern Liquid Chromatography (3rd edn), and High-Performance Gradient Elution, are standard references on thousands of desks around the world. He has taught HPLC training classes around the world to more than 10,000 students.

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