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In this article we’ll look at flow-rate and particle-size adjustments.
In prior instalments of this series on method adjustment, we’ve looked at the guidelines from the European Pharmacopoeia (EP) and United States Pharmacopoeia (USP) for allowable adjustments in pH (Part 1), mobile phase (Part 2), and column dimensions (Part 3). In this article we’ll look at flow-rate and particle-size adjustments.
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John Dolan is considered to be one of the world’s top experts in HPLC. He has written more than 300 user-oriented articles on HPLC troubleshooting over the last 30 years, in addition to more than 100 peer-reviewed technical articles on HPLC and related techniques. His three books (co-authored with Lloyd Snyder), Troubleshooting HPLC Systems, Introduction to Modern Liquid Chromatography (3rd edn), and High-Performance Gradient Elution, are standard references on thousands of desks around the world. He has taught HPLC training classes around the world to more than 10,000 students.