MOBILion Systems, Inc. announced plans to showcase the expanding impact of its proprietary SLIM (Structures for Lossless Ion Manipulation) technology across the full spectrum of mass spectrometry. At the 74th Annual American Society for Mass Spectrometry (ASMS) conference, the company will highlight how SLIM high-resolution ion mobility enables cleaner, faster, and more information-rich mass spectrometry data. The applications span PFAS analysis, drug discovery, biopharmaceutical characterization, proteomics, lipidomics, metabolomics, food testing, and clinical and translational research.
When integrated upstream of mass spectrometry, the technology has the potential to improve performance across all detector classes. These include nominal-mass quadrupole systems, high-resolution QTOF platforms, and next-generation proteomics systems. This multi-platform capability positions the technology as a highly differentiated platform asset for mass spectrometry vendors seeking to advance their analytical portfolios.
“MOBILion’s mission has always been to reveal what conventional LCMS workflows leave unseen,” explains Melissa Sherman, Ph.D., Founder and CEO of MOBILion Systems. “With our high-resolution ion mobility mass spectrometry platform, MOBIE, customers are already demonstrating value in demanding real-world applications. With the PAMAF™ (Parallel Accumulation with Mobility Aligned Fragmentation) configuration and our proteomics work, we are demonstrating that SLIM can go further, changing how ions are separated, selected, fragmented, and converted into actionable biological insights. As legacy architectures approach practical performance limits, SLIM offers a route to redefine an entire mass spectrometry portfolio from low- to high-resolution systems, rather than a single workflow or product line,” she adds.
The company's platform strategy spans three high-value mass spectrometry opportunities:
- A QTOF configuration optimized for proteomics: Powered by Parallel Accumulation with Mobility Aligned Fragmentation (PAMAF), this configuration improves ion utilization to deliver deeper proteome and PTM coverage with greater sensitivity, speed, and accuracy.
- A QTOF integration for non-proteomics workflows: This architecture reduces interferences and improves data quality, leading to faster and higher-value insights.
- A new SLIM-enabled QQQ mode of operation: Called Parallel Accumulation Mobility Aligned Targeting (PAMAT), this mode is designed to deliver industry-leading sensitivity and robustness capable of redefining targeted workflow performance with increased throughput, quantitative accuracy and precision.
This unified strategy uses SLIM high-resolution ion mobility to improve how ions are separated, transmitted, fragmented, and interpreted across mass spectrometry to enhance instrument performance. The cleaner, richer data generated by these instruments can be leveraged to strengthen downstream artificial intelligence workflows. As laboratories increasingly seek to accelerate and automate data analysis and extract more insights from complex datasets, this ability to generate cleaner data becomes a strategic advantage.
This article is based on a press release issued by MOBILion Systems, Inc.
