Fried egg in a pan
Application Notes

Obtaining Ultrapure Water for Sensitive PFAS Analysis by LC-MS

Learn how sensitive PFAS testing according to the draft EPA 1633 method can be performed with ultrapure water from a Milli-Q® IQ system, which eliminates detectable PFAS for reliable LC-MS/MS results. 


Application note for obtaining ultrapure water for sensitive PFAS analysis by LC-MS

Per-and polyfluoroalkyl substances (PFAS) have been used worldwide in industry since the 1940s. PFAS are man-made chemicals, made of a carbon chain of variable length with very stable carbon-fluorine bonds. Their unique water-, grease-, and stain-resistant properties make them ideal for many products, such as food packaging, nonstick cookware, water repellent and stain-resistant fabrics, cosmetics, and firefighting foams. They are also critical in the manufacture of many products important for modern life, including medical technologies, semiconductors, batteries, phones, automobiles and airplanes.

To obtain reliable and accurate analyses of PFAS, it is important to use ultrapure water free of detectable levels of PFAS.

In this application note, ultrapure water from a Milli-Q® water purification system was tested for PFAS according to the draft EPA 1633 method. None of the 40 PFAS compounds tested were detected in the ultrapure water produced by a Milli-Q® IQ 7000 system fitted with a LC-Pak® polisher at the point-of-dispense, making it suitable for the most sensitive PFAS analyses by LC-MS/MS.

Download this application note to learn about:

  • The importance of using ultrapure water in sensitive PFAS analysis
  • Sources of potential PFAS contamination
  • The components of an optimal water purification system for PFAS analyses
  • Environmental and health implications of persistent PFAS contamination
  • The  critical role of ultrapure water in PFAS analysis
  • The effectiveness of a Milli-Q® ultrapure system in eliminating PFAS from water

*The Life Science business of Merck, KGaA, Darmstadt, Germany operates as MilliporeSigma in the U.S. and Canada.

For further information about our names in the US, Canada, and internationally, please refer to our disclaimer at merckgroup.com.

Sponsored by

  • Merck logo