Per- and polyfluoroalkyl substances (PFAS), known for their environmental persistence and potential health impacts, are a significant concern in water quality management. This study demonstrates the utilization of the EPA Method 1633 to analyze and quantify 40 PFAS chemicals in water samples. The technique utilizes liquid chromatography combined with tandem mass spectrometry (LC-MS/MS) after a solid-phase extraction (SPE) using Supelclean™ ENVI-WAX™ SPE cartridges. The procedure allows for highly sensitive detection and quantitation of PFAS analytes in various matrices. Performance evaluation demonstrated that recoveries for all 40 PFAS compounds and 24 isotopically labeled standards (EIS) were within the typical EPA acceptable range of 70-130% with low corresponding standard deviations, indicating high precision and robustness. The method's suitability for comprehensive PFAS analysis in environmental samples underscores its value for regulatory compliance and environmental monitoring.
Download this application note to:
- Learn how to get the most from EPA 1633 by evaluating consumables and your workflow to ensure accuracy and repeatability.
- Explore The role of LC-MS/MS combined with solid-phase extraction (SPE) in achieving high sensitivity and accuracy
