Gloved hand extracting water sample from river in a conical flask
Thought Leadership

PFAS Testing Realities: Method, Matrix, and Contamination Control

Three specialists share what they learned developing PFAS methods and supporting laboratories at production scale.


Cover of Executive Overview showing gloved hand  extracting water sample from river in a conical flask

While EPA methods define the PFAS testing framework, labs running hundreds of samples encounter practical gaps that the documents omit. From untargeted screening decisions to contamination control at part-per-trillion levels in sludge and blood, analysts need answers beyond published protocols.

This executive summary captures a roundtable in which PFAS specialists from Phenomenex and SCIEX discuss how they develop methods under production pressures. They explain how standards drive method scope, when to shift from water-style prep to full anion-exchange SPE, and how LC-MS/MS choice drives workflow economics and stability.


Download the executive summary to:

  • See why standard availability creates the bottleneck in PFAS method development
  • Learn when untargeted screening justifies the cost before committing to full characterization workflows
  • Understand how container material affects PFAS recovery and which vessels prevent adsorption at ultra-trace levels

Meet the Experts:

          samlodge
Sam Lodge
Environmental Senior Business Development Manager, Phenomenex 
Sam Lodge is the Phenomenex Senior Business Development Manager for the Environmental industry. He has been with Phenomenex for more than 30 years in roles including Key Account Manager and Senior International Sales Manager, and is a product expert in SPE and HPLC chemistries. Over the past eight years, he has worked extensively with commercial and government laboratories on PFAS analytical methods, including the validation of EPA 533, the MLV for DM 1633, and multiple internal (MOD) methods.
          karl-otjen
Dr. Karl Oetjen 
Market Development Manager for Environmental, Industrial, Food & Beverage, SCIEX 
Karl Oetjen is a Market Development Manager for Environmental, Industrial, and Food & Beverage at SCIEX with more than 10 years of mass spectrometry experience. He earned his PhD in Hydrologic Science and Engineering from the Colorado School of Mines, where he focused on nontarget characterization of surfactant mixtures, including firefighting foams. His work identified several novel PFAS now found in environmental and industrial samples. At SCIEX, he supports laboratories developing quantitative and qualitative screening methods.
          simon-roberts-
Simon Roberts
Staff Scientist, SCIEX
Simon Roberts is a Staff Scientist at SCIEX and completed a postdoctoral fellowship at the Colorado School of Mines, where he worked with Dr. Christopher Higgins and Dr. Jennifer Field to identify new PFAS classes in aqueous film-forming foams. At SCIEX, he focuses on method optimization and data reporting, helping laboratories set up PFAS and other environmental analytical methods.

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