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Scaling TIMS Mass Spectrometry From 10 to 500 Samples Per Day

Bruker’s TIMS technology moves from low-throughput experiments to hundreds of samples per day, driven by sensitivity, scale, and robustness.
Written bySeparation Science
InterviewingRohan Thakur

Rohan Thakur, PhD, President of Bruker Daltonics, highlights a core performance theme behind Bruker’s TIMS technology: depth combined with speed. Early TIMS workflows supported roughly ten samples per day. Current implementations reach about 500 samples per day while maintaining high sensitivity. This shift reflects a focus on robustness alongside throughput. High-scale operation demands stable performance across long sequences and diverse sample types. Thakur frames robustness as a prerequisite for converting raw instrument capability into practical laboratory productivity.

He also points to Bruker’s engagement with the research community through an extensive key opinion leader program. These collaborations support scientists pushing technical boundaries. Thakur cites Dr. Jacob Geri, Assistant Professor of Pharmacology at Weill Cornell Medical College, as an example, noting work on shift reagent strategies within a TIMS cell. Such efforts expand what TIMS-based systems can measure and resolve. The combined emphasis on scale, sensitivity, and scientific partnership positions TIMS workflows for both discovery and routine analytical environments.

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Interviewing

  • Rohan Thakur

    Rohan Thakur is the President of TOFWERK, a Bruker company. Rohan has over 25 years of experience in MS, including 14 years in applications and MS development. He is the owner of several patents in the field of MS. Thakur has over 20 years managing businesses with full P&L responsibility of multi-national corporations, and a strong track record of building a high-growth, high-margin organization that outperforms competition.

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