Split Sample Introduction – Part 1: Background and Split Ratio

Part 1 in this series introduces the split sample concept and things to take note of for the best analytical results possible.

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byMatthew Klee

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This technical article introduces the split sample concept and things to take note of for the best analytical results possible.

Anyone who analyses samples by capillary gas chromatography has most likely used a split inlet. Although simple in concept, there are a few things to keep in mind to get the best analytical results possible.
Split inlets were invented to address the issues originally faced with the invention and adoption of capillary columns. Wall coated open tubular (WCOT) capillary columns offer much higher plate count, and, therefore, much higher separation power than the previously used packed column counterparts. However, they suffer from two major deficiencies: lower capacity and the need to produce narrow initial band widths even though the column flow-rate is low.

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Meet the Author(s):

Matthew Klee
Dr Matthew S. Klee is internationally recognized for contributions to the theory and practice of gas chromatography. His experience in chemical, pharmaceutical and instrument companies spans over 30 years. During this time, Dr Klee’s work has focused on elucidation and practical demonstration of the many processes involved with GC analysis, with the ultimate goal of improving the ease of use of GC systems, ruggedness of methods and overall quality of results.

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