Chromatography Forum

This abstract halftone image symbolizes the differences between reversed and normal phase HPLC, highlighting the importance of method choice in chromatographic resolution.

Reverse Phase vs Normal Phase HPLC: How to Choose the Right Tool

When resolution counts, choosing the right phase can make or break your method. Here's what lab veterans say.

Fixing GC Peak Tailing for Cleaner Results

Discover lab-tested techniques to correct gas chromatography peak tailing and enhance separation efficiency.

Peak Purity in HPLC: Assessment, Troubleshooting, and Best Practices

Learn how peak purity assessment in HPLC helps detect coelution and improve impurity profiling for more reliable quantification.

C8 vs C18 Column: Which Should You Choose?

byAimee Cichocki

Explore the key differences between C8 and C18 HPLC columns and how they can impact results

This image visualizes signal-to-noise ratios, a key parameter defined by USP <621> for chromatographic analysis. It underscores the importance of clear signals above baseline noise in achieving sensitivity and meeting regulatory standards.

USP Signal-to-Noise Ratios: Standards and Challenges in Chromatography

This image represents baseline drift in HPLC (High-Performance Liquid Chromatography), where irregular peaks and fluctuations in the baseline impact data stability. Baseline drift can obscure low-intensity peaks, affecting the reliability of HPLC results. The article provides troubleshooting steps to address common causes like solvent quality, air bubbles, and equipment issues, enhancing chromatographic accuracy.

Why Your HPLC Baseline Drifts—And How to Stop It

When GC Retention Times Shift: Practical Advice for Operators

Understanding HPLC Column Loading Capacity: Insights from the Chromatography Community

byAimee Cichocki

Optimizing HPLC Pressure: Real Solutions for Better Performance

Understanding MRM Fundamentals: Dwell Time, Cycle Time, and Duty Cycle

Factors Impacting Chromatography Retention Time

byAimee Cichocki

Conquer Ghost Peaks in HPLC: Identification and Elimination

Harnessing Eco-Friendly Solvents for Greener Liquid Chromatography

GC Column Bleed: Causes and Prevention

byAimee Cichocki

GC-FID: 5 Must-Know Tactics For Optimal Performance

Optimizing Manual Peak Integration in Chromatography

byAimee Cichocki

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