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SCIEX

Separation Science

In this study, an immunoaffinity high resolution accurate mass (HRAMS) assay is presented as a complementary analytical technique for signature peptide quantification. The assay performance is measured using Trastuzumab in rat plasma as a case study.

Addressing the key challenges in the quantification of Trastuzumab

Blogs

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In this technical note the in-vitro metabolism of a model therapeutic peptide Bivalirudin was investigated to highlight the new peptide catabolism workflow features of MetabolitePilot 2.0 software.

Therapeutic peptide catabolite identification

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In this technical note the ADC specific workflow features of the new MetabolitePilot 2.0 were used to identify payload products and metabolites from two noncleavable linker ADCs after incubation with human liver lysosomes and S9 fraction.

Metabolite identification of payload species of antibody drug conjugates

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Discover a procedure for the simultaneous determination of prescription and designer benzodiazepines in urine by SPE and LC-MS/MS.

Simultaneously determine prescription and designer benzodiazepines in urine by SPE and LC-MS/MS

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Thermo Fisher Scientific

This compendium provides detailed methods for the analysis of trace elements in pharmaceutical products using AAS, ICP-OES and ICP-MS covered by the NEW USP chapters 232 and 233.

Trace element analysis of pharmaceutical products

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Shodex

This application note demonstrates a rapid LC/MS method for quantifying polysorbate (Tween) in the presence of IgG and NaCl as matrixes, without the need of sample pre-treatment using a polymer-based reversed-phase column, Shodex™ ODP2 HP-2D.

Method for LC/MS analysis of aggregates and additives in antibody drugs

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Restek

This application note presents a simple dilute-and-shoot method that provides a fast 3.5 minute analysis of fentanyl and related compounds in human urine by LC-MS/MS using a Raptor Biphenyl column.

A simple dilute-and-shoot method for the analysis of fentanyl and its analogues in human urine by LC-MS/MS

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CAMAG

Application note describing the HPTLC methodology to identify sibutramine in herbal weight loss products.

Detection of Sibutramine in Slimming Products by HPTLC and Confirmation by HPTLC-MS

This application note describes the different possibilities for Cannabis testing by HPTLC.

Effective Cannabis Testing with HPTLC

Gas chromatograph mass-spectrometer with ampoules

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Agilent

This application note demonstrates the separation of enantiomers of amphetamines and their positional isomers on chiral phase columns using SFC with mass spectrometry

Separation of Amphetamine Enantiomers by SFC

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Separation Science Spectroscopy Solutions Series

NMR Structural Techniques for drug candidate discovery and development. Impact range from drug screening, identification and structure characterization, structure based design, impact on in vitro and ex vivo studies on biological fluid and tissues, and on in vivo studies on organs or animals.

Structural NMR Techniques: Contribution to the Drug Discovery & Development

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Waters

Preparative-scale chromatography is used in applications where compounds are synthesized, identified, isolated, purified, characterized, screened, tested. Waters AutoPurification Systems scalable prep configurations offer the specificity of mass-directed purification or inclusiveness of a UV system.

Pharma Drug Discovery