Polyethylene Glycol 3350 (PEG-3350) is a widely used excipient in pharmaceuticals, consumer products, and food—but its viscous nature makes impurity testing difficult. Residuals ethylene oxide and acetaldehyde are of particular concern, as both compounds are under strict regulatory scrutiny and have been linked to recalls. Traditional gas chromatography–mass spectrometry (GC-MS) requires extensive sample preparation and complex workflows that slow throughput and increase variability. This application note demonstrates how Molecular Rotational Resonance (MRR) spectroscopy provides a smarter alternative. Using the BrightSpec-MRR™ platform with direct headspace sampling, ethylene oxide and acetaldehyde in PEG-3350 can be quantified quickly, accurately, and reproducibly, with minimal prep and results that meet USP acceptance criteria. The note highlights how MRR reduces analysis time to under 10 minutes and simplifies compliance testing for PEG excipients.
Download this application note to:
- Learn how MRR delivers direct, headspace-based impurity testing with minimal preparation.
- Review data showing strong analytical performance and LOQs aligned with USP thresholds.
- Discover how the BrightSpec-MRR™ platform increases throughput and simplifies compliance testing compared to traditional methods.
