PFAS testing has moved into full compliance mode. Laboratories must now reach sub-trace thresholds across food and water while producing results regulators can trust. The challenges extend beyond sensitivity: contamination from routine consumables, background signal that accumulates in the instrument, and shifts in retention that erode confidence over long runs.
This executive summary captures lessons presented by SCIEX specialists based on applied residue-testing studies. They point to practical steps such as using smaller injections to reduce matrix effects and applying selective SPE to improve recovery. Their experience also highlights the importance of isomer separation and careful use of internal standards to ensure results hold up under regulatory review.
Download this executive summary to learn:
- Ways to qualify and archive consumable lots that minimize PFAS background
- Method adjustments that improve retention stability for challenging PFAS compounds
- Why resolving branched and linear isomers is critical for accurate PFAS quantitation
- Where automated QC flags can shorten review time and strengthen data confidence
Meet the Experts:
 | Jianru Stahl-Zeng Senior Technical Marketing Manager, SCIEX Jianru joined SCIEX in 2001, first supporting applications in proteomics and small molecules before moving into technical marketing. She now leads EMEA technical marketing and serves as Global Technical Leader for food and environmental applications, guiding projects that advance residue testing methods worldwide. |
 | Simon Roberts Staff Applications Scientist, SCIEX Simon has nearly 15 years of experience researching PFAS in the environment, beginning as a postdoctoral fellow at the Colorado School of Mines. At SCIEX, he specializes in method optimization and reporting, helping commercial, government, and academic labs across North America establish and troubleshoot PFAS and environmental analytical workflows. |
