Methylmalonic acid testing materials including syringes and capsules.

methylmalonic-acid-detection

LC&ndash;MS/MS expert Bryan Tackett explains how supported liquid extraction and polar-embedded chromatography improve the accuracy and reliability of methylmalonic acid quantification in serum.

Precision in Vitamin B12 Assessment: Optimized LC&ndash;MS/MS Method Enhances Methylmalonic Acid Detection

Articles

Helium's position in the periodic table, relevant to GC-MS discussions

helium-shortage-impact-on-gc-ms

Helium shortages push labs to rethink carrier gas strategy. Hydrogen and nitrogen offer viable paths, but each demands careful method optimization and safety planning.

Rethinking Carrier Gases in GC and GC&ndash;MS: Moving Beyond Helium

Detailed view of an inert GC column used in analytical chemistry

gc-column-inertness

GC column inertness enhances performance, reducing bleed to improve sensitivity for challenging analytes. Discover the benefits today!

Why GC Column Inertness Still Shapes Difficult GC Analyses

Abstract visualization of data integrity and agentic AI in laboratories

agentic-ai-in-the-lab

Explore how agentic AI in the lab revolutionizes workflows by balancing automation with scientific oversight for improved efficiency.

Agentic AI in the Lab: Laying the Foundations for Real-World Use

Drain with swirling water, emphasizing the need for broader PFAS approaches.

targeted-pfas-methods

Explore how targeted PFAS methods miss broader fluorinated compounds and the role of adsorbable organic fluorine in analysis.

Enhancing Targeted PFAS Methods With Broader Fluorine Measurements

Diverse food spread on a wooden table, perfect for food safety testing discussions.

automated-sample-preparation

Automated robotic liquid handling for sample preparation integrates with GC-MS to overcome the bottleneck of manual extraction. This eliminates human error, ensures regulatory compliance, and handles complex matrices.

Automated Sample Preparation: Eradicating Matrix Interferences in High-Throughput Food Safety Testing

Assorted colorful pharmaceutical pills and capsules on a white surface, representing the expanding pipeline of accessible therapeutics driven by Next-Generation Biosimilar Development.

next-generation-biosimilar-development

A deep dive into the FDA&rsquo;s evolving 2025 and 2026 draft guidances, which pivot biosimilar approval away from traditional clinical efficacy trials and heavily toward high-resolution analytical comparability and targeted pharmacokinetic studies.

Next-Generation Biosimilarity: Leveraging Advanced Analytical Techniques and PK Data to Meet New FDA Guidance

3D rendering of a multi-colored adeno-associated virus (AAV) capsid, highlighting structures critical to AAV manufacturing scale up.

aav-manufacturing-scale-up

Insights into transitioning AAV production from adherent cultures to scalable suspension systems, focusing on analytical quality control, advanced separation techniques, and regulatory comparability.

Scaling Viral Vector Manufacturing: Transitioning AAV Production from Adherent to Suspension Systems

Abstract representation of analytical authentication workflows with data patterns

analytical-authentication-workflows

Analytical authentication workflows shift from expert interpretation to AI-assisted systems, improving efficiency in distinguishing real products.

Analytical Authentication Workflows Scale with Data, AI, and Field Deployment

3D molecular structure representing peptide engineering for GLP-1 therapeutics

peptide-engineering-for-therapeutics

Characterizing complex GLP‑1 and dual‑agonist therapies requires advanced orthogonal separations and high‑resolution mass spectrometry.

The Analytical Separation Engine Driving the Next Generation of GLP‑1 Therapeutics

An array of gas tanks, reflecting the helium vs hydrogen cost analysis

helium-vs-hydrogen-cost-analysis

As global supply volatility impacts analytical supply chains, we provide the technical and financial case for transitioning to on-site hydrogen generation in the modern GC laboratory.

Helium vs Hydrogen Cost Analysis: A Guide for Lab Managers in 2026

A grocery store aisle displaying various food products, reflecting the importance of GC-SCD for ensuring flavor stability during food reformulation.

sulfur-chemiluminescence-detection

Trace sulfur compounds, with their low odor thresholds, pose challenges for standard MS detection. GC-SCD overcomes matrix masking, ensuring flavor stability during food reformulation.