Laboratory setup for PFAS troubleshooting with colored vials

pfas-troubleshooting

PFAS failures often produce similar symptoms. A structured diagnostic sequence helps laboratories find the source without repeating the entire workflow.

PFAS Troubleshooting Guide: Contamination, Carryover, Low Recovery, and Ion Suppression

Articles

Advanced filtration equipment for bioprocess intensification

sd-2156911277-downstream-filtration-bioprocess-intensification

R&amp;D Manager Nicholas Marchand discusses mitigating virus filter fouling, optimizing scale-down models, and evolving single-use flow paths for high-titer feedstreams.&nbsp;

Overcoming Downstream Filtration Bottlenecks in Intensified Biomanufacturing&nbsp;

A scientist reviews gas chromatography method parameter setpoints on an instrument control monitor in a modern analytical laboratory.

choosing-initial-gas-chromatography-setpoints-temperature-flow-pressure

Choosing the right initial GC method parameters avoids wasted runs. Set oven temperature, carrier flow, and inlet conditions sensibly from day one.

Choosing Initial GC Setpoints: Temperature, Flow, and Pressure

A laboratory scientist examines an analytical GC column at a workstation, with column specification documents and sample vials on the bench.

select-gas-chromatography-columns-inlets-detectors

GC column selection shapes every separation result. Match your stationary phase, inlet, and detector to the sample before touching the instrument.

How to Select GC Columns, Inlets, and Detectors

Molecular structure representing traditional ADME workflows

traditional-adme-workflows

Traditional ADME workflows may mislead PROTAC data, presenting challenges in absorption and metabolism.&nbsp;

Why Traditional ADME Often Fails for PROTACs

Laboratory staff reviewing PFAS data on computer screen

pfas-data-review

PFAS data review must confirm peak identity, quantitation and quality-control performance before results reach the final report.

From Chromatogram to Report: How to Review PFAS Results

Engineer monitoring advanced chromatography system

sd-1165145549-advanced-chromatography

Dr. Young Li explores the physical drivers of scale-up resolution loss, bed stability in wide columns, high-titer feed challenges, and strategies for transitioning to continuous manufacturing.

Mastering Chromatography Scale-Up: Expert Insights on Column Dynamics, Heavy Feeds, and Continuous Processing

Scientist analyzing PFAS quality control samples in a lab

pfas-quality-control

PFAS batch review must connect blanks, recoveries, calibration and sample-specific controls before results can be released.

PFAS Quality Control: How to Review and Accept an Analytical Batch

Hand checking PFAS method validation process

pfas-method-validation

A structured performance study shows whether a PFAS method can meet its intended purpose under the laboratory&rsquo;s own operating conditions.

How to Validate or Verify a PFAS Method

Hand holding LC-MS/MS columns for PFAS analysis

pfas-lc-msms-method-development

Reliable PFAS measurement depends on chromatographic control, selective detection and a clear understanding of matrix response.

How to Develop a Reliable PFAS LC-MS/MS Method

Laboratory equipment for matrix effect evaluation in HPLC.

matrix-effects-in-hplc-and-lc-ms

Learn to identify signal suppression and enhancement in HPLC and LC&ndash;MS, calculate matrix factor (%MF), implement stable-isotope internal standards, and optimize sample clean-up under regulatory guidelines.

Matrix Effects in HPLC and LC&ndash;MS: Causes, Detection, and Mitigation Strategies

Researchers in lab focused on quality control and traceability

traceability-and-certified-reference-materials-in-quantitative-analysis

Master metrological traceability chains under ISO/IEC 17025 and ISO 17034 guidelines. Learn to select Certified Reference Materials (CRMs), account for purity uncertainties, and prevent stock standard degradation.