Volatile organic compounds (VOCs) in exhaled breath and biological fluids are increasingly studied as measurable indicators of human health, or biomarkers. With robust sampling protocols and sensitive analytical techniques, VOC analysis provides a practical and scalable approach for monitoring human health—enabling early detection of disease, tracking physiological changes, and supporting the drive towards personalized healthcare.
This collection presents case studies highlighting how thermal desorption (TD) coupled with gas chromatography-mass spectrometry (GC–MS) and advanced chemometric analysis can uncover distinct biomarkers associated with specific health conditions.
Featured applications include high-throughput cancer screening, species-level identification of bacterial pathogens, and monitoring of infection progression in malaria. Collectively, these studies demonstrate reproducible and scalable workflows that contribute to clinically relevant research, from early discovery through to clinical validation.
A valuable resource for analytical chemists, clinical researchers and those involved in biomarker discovery, this eBook summarizes recent advancements and practical insights into the current landscape and future potential of VOC analysis in biomarker discovery.
What you will learn:
- Practical insight into VOC sampling and analysis workflows using thermal desorption and GC–MS, including approaches for handling complex biological matrices.
- Examples of real-world biomarker discovery studies demonstrating how VOC analysis is applied in oncology, infectious disease, and microbiology research.
- An overview of scalable, high-throughput methods suitable for clinical research and diagnostic development, with a focus on reproducibility and data quality.
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