Waters Corporation introduced the Waters Xevo MRT P10 Mass Spectrometer, a high-resolution Quadrupole Time-of-Flight (QToF) System engineered for high-throughput multi-omics, bioanalysis, and biopharmaceutical laboratories. Showcased at the 74th ASMS Conference on Mass Spectrometry and Allied Topics, the platform accelerates biomarker discovery and validation across large-cohort biomedical research and epidemiology studies.
The system addresses data-bottleneck challenges by offering up to a 20-fold increase in MS/MS sensitivity compared to its predecessor, thereby helping scientists detect low-abundance compounds in complex samples. Operating at acquisition speeds twice those of its predecessor, the platform is the fastest benchtop high-resolution mass spectrometer currently available. This speed enables high throughput alongside exceptional resolution and sub-ppm mass accuracy, delivering high data confidence.
When combined with the DESI XS ion source, the system unlocks rapid spatial analysis down to the cellular level at up to 200 Hz. This configuration increases sample throughput six-fold while preserving high image quality, setting a new benchmark for speed in high-resolution spatial analysis. In comparative lipid profiling studies using LC-MS/MS, the system identified up to 40% more lipids than the leading alternative benchtop high-resolution mass spectrometer.
Working in analytical science?
Register for a FREE Separation Science account to subscribe to the Separation Science Newsletter.
James Hallam, Vice President and General Manager, Liquid Chromatography-Mass Spectrometry, Waters Analytical Sciences, Waters Corporation, highlights the performance capabilities. "By combining enhanced MS/MS sensitivity, the industry’s fastest benchtop acquisition speeds, and advanced intelligent acquisition modes in LC-MS/MS – and layering in a new benchmark for MS imaging speed and throughput with our DESI XS – this platform empowers researchers to see more biology, accelerate discovery, and make confident decisions."
Core research facilities utilize the system's performance to navigate complex analytical demands. "Its excellent resolution enables us to separate signals of similar mass at very high acquisition speeds, delivering deep, high-quality coverage while maintaining sub - ppm mass accuracy," states Corey Broeckling, Ph.D., Director of the Bioanalysis and Omics Center at Colorado State University.:
Global availability for the platform is expected to begin in Summer 2026.
This article is based on a press release issued by Waters Corporation.
