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Mass Spectrometry

 
 

In this section you'll find a selection of valuable learning materials relating to the use and application of mass spectrometry and related techniques, including technical articles, applications, webinars and eSeminars.

 
 
 
 
 

Webinars

Expand Your Metabolomics Horizons

Presenters:  Steven Fisher (Market Director - A&G/Life Science Research Segment, Agilent Technologies), Christine Miller (Omics Market Manager, Agilent Technologies) and Steve Madden (Software Product Manager, Agilent Technologies)
Sponsor:  Agilent Technologies

 

Performance of Agilent Supplies for PerkinElmer ICP-OES and ICP-MS Systems with Water, Food and Environmental Samples

Presenters:  Eric Vanclay (Agilent Technologies, Melbourne, Australia)
Sponsor:  Agilent Technologies

 

Accelerating Large Molecule LC-MS Method Development

Presenters:  Ian Moore (Global Technical Marketing Manager, Pharma Applications, SCIEX)
Sponsor:  SCIEX

 

Applying ICP-MS to Speciation and Quantitative Analysis of Arsenic in Foodstuffs and Beverages

Presenters:  Antonio Signes-Pastore (Queen's University, Belfast, UK) & Simon Nelms (Thermo Fisher Scientific, UK)
Sponsor:  Thermo Fisher Scientific

 

MS Solutions

MS Solutions #28: Quality: The Third Side of the Analytical Success Triangle

As analytical chemists, we spend considerable time thinking about and working with basic scientific principles combined with the technology and products that allow us to solve our analytical problems. However, it is essential for success of any method and for the long-term success of a laboratory operation that our science and technology are supported by a quality system that ensures continuing achievement of our operational goals. We therefore present a triangle concept for analytical success: One side of the triangle shows our need to understand fundamental scientific concepts. A second, and equally sized side, is the ability to apply current technology, applications, software, and techniques in the laboratory. Finally, the base of this equilateral triangle is the quality system. If any one side of the triangle is given inadequate attention or, worse yet, is missing then we cannot hope to achieve overall success for the laboratory operation.

 

MS Solutions #27: The Importance of the Limits Option in the NIST Mass Spectral Search Program Especially When Used with the Wiley Registry of Mass Spectral Data

Over the last several editions, starting with at least the 6th edition, the Wiley Registry of Mass Spectral Data has contained a number of “single-peak” spectra such as those shown in Figure 1. Such spectra in an EI database used for the identification of unknowns based on their mass spectra are of no benefit.

 

MS Solutions #26: FAIMS/DMS Applications Overview

In last month’s edition of MS Solutions I described the technology behind Field Asymmetric Ion Mobility Spectrometry (FAIMS), also known as Differential Mobility Spectrometry (DMS). In that article we learned that ions of identical m/z value may be separated in a FAIMS/DMS device based on their mobility differences in a high potential electrical field. In this month’s article we are going to look at the incorporation of FAIMS/DMS into a conventional LC/MS system to provide an added dimension of ion separation which is orthogonal to both chromatographic and mass spectrometric separation mechanisms.

 
 

Apps

Interlaboratory Tests Demonstrate the Robustness and Transferability of the Toxtyper Workflow

Here we describe a robust and automated research based screening solution for the detection and identification of drugs and drugs of abuse in biological specimens. The workflow was tested with regard to method- and result-transferability from lab to lab.

 

Toxtyper – a Comprehensive LC-MS Screening Solution for Clinical and Forensic Toxicology

Here we describe a robust and automates research based screening solution based on the latest LC-MSn ion trap technology that promises to provide a combination of the highest performance LC-MS/MS and easy-to-use identification with the greatest transferability of results from lab to lab.

 

Authenticity Assessment of Fruit Juices using LC-MS/MS and Metabolomic Data Processing

In this study, the feasibility of LC-MS/MS techniques employing Q TRAP and TripleTOF systems for metabolomic-based authentication of fruit juices (including apple, blueberry, cranberry, grapefruit, orange, pomegranate, and their mixtures) was explored.

 
 
 

Separation Science, in collaboration with Thermo Fisher Scientific, has developed a webinar microsite featuring presentations that cover new methods and applications in food and beverage analysis. Current on-demand presentations include:

Automated Malt Analysis using Discrete Analyzers
by Aaron McLeod

Direct Analysis of Food and Beverages using SPME-GC-MS/MS - No Sample Cleanup, Automated and Highly Specific
by Elena Ciceri

HPAE-PAD for Prebiotic Ingredient Characterizations
by Parul Angrish & Manali Aggrawal

Applying ICP-MS to Speciation and Quantitative Analysis of Arsenic in Foodstuffs and Beverages
by Antonio Signes-Pastore & Simon Nelms

The microsite is free to access, and more presentations will be added.