Advances in PFAS Analysis


Understand essential details for successful PFAS analysis and optimize EPA Method 1633 in your lab.

By watching this eSeminar, you will:

  • Gain practical insights into optimizing sample preparation in alignment with EPA Method 1633’s regulatory requirements by the use of dual-phase SPE cartridges, covering background analysis, MDL studies, and recoveries
  • Benefit from real-world experiences from Complete Environmental Testing, offering valuable insights on navigating EPA 1633 in an end-to-end workflow, while utilizing dual-phase SPE cartridges to improve laboratory efficiency
  • Understand key details for successful PFAS analysis
  • Learn how to optimize analysis for ultra-short chain PFAS compounds
  • See how to expand the range of PFAS compounds to analyze in a single run

Event Overview

Separation Science, in collaboration with its sponsors Waters and Restek, is pleased to bring you an online eSeminar focusing on advances in PFAS analysis. This unique event brings together key experts in the field and provides an interactive learning environment for scientists working in this industry.


Efficiency in EPA Method 1633: Validation and Implementation Strategies
by Jeffrey Smith, Director of Operations, Complete Environmental Testing (CET)

This presentation focuses on optimizing EPA Method 1633 in your laboratory highlighting the validation and implementation of dual-phase WAX and GCB cartridges. EPA 1633 establishes a method for the determination of 40 PFAS from challenging matrices such as non-potable waters, soils, biosolids, and tissue. For these matrix types, sample preparation has moved beyond the use of a WAX cartridge alone. GCB has been added to the sample preparation workflow to provide additional sample cleanup. We discuss the full EPA 1633 workflow, including topics such as background analysis for soils and water, MDLs achieved, observed recovery in authentic samples, and the practical advantages of dual-phase cartridges in reducing manual labor steps compared to loose GCB in EPA 1633.

This presentation is designed for scientists, laboratory managers, and others looking to implement and validate EPA Method 1633 or optimize their sample preparation process in their current workflow. Listen as Complete Environmental Testing shares experiences on working with the complex matrices in EPA 1633 and breaks down advantages in their method workflow with the use of dual-phase SPE cartridges.

Untapped Ultrashort-chain PFAS Analysis Combined with Routine PFAS Analysis in a Single LC-MS/MS Run
by Mike Chang, Market Development Manager, Restek Corporation

Starting from measuring C8 many decades ago, today’s PFAS testing requires a lot more chromatography capabilities when an extended list of PFAS analysis is desired. Chain length ranging from C1 to C18 and a functional group changing from carboxylic acids to ethers, sulfonamides, and more, with multiple oxygens in the structure, can be challenging for a chromatograph all in one run. In this presentation, we see examples of a combined PFAS panel analyzed in one run with chain length from C1 and above, in addition to AFFF and FTS compounds.

What you need to know:

Format: On-demand

Duration: Approximately 60 minutes


Jeffrey Smith
Director of Operations, Complete Environmental Testing (CET)

Jeffrey Smith holds a BS in Chemistry from Quinnipiac University. He has been working in environmental analytical chemistry for 18 years, with experience in several disciplines, including GC/MS and LC-MS/MS. Jeffrey now serves as the director of operations at Complete Environmental Testing. For the past few years, his focus as director has been building the PFAS department at CET from the ground up, including method development and researching LC/MS/MS instrumentation for the laboratory. Jeffrey serves on several PFAS work groups and is an active member of the Reasonable Confidence QA/QC Protocols work group for the state of Connecticut.

Mike Chang
Market Development Manager, Restek Corporation

With an analytical chemistry background and 15+ years of experience in the chromatography industry, from instrumentation to applications, Mike is the key liaison to testing agencies and industries, bringing better ways of measuring contaminants in the environment and food. He has been chairing PFAS sessions and presenting PFAS topics at various conferences.


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