A comprehensive course in the systematic development of liquid chromatography separations using QbD principles. Here we look at QbD and how we can use it to help develop more robust methods. We review the variables that affect selectivity and prioritize them in light of QbD principles.
This course is designed for practical workers in the laboratory who have responsibility for designing new HPLC or UHPLC methods or transferring methods between laboratories. Experienced workers will get the most out of this class, but because it builds from the fundamentals, anyone with experience in HPLC or UHPLC will gain valuable knowledge.
This course covers:
Here we look at QbD and how we can use it to help develop more robust methods. We review the variables that affect selectivity and prioritize them in light of QbD principles. An example is given for development of a method using QbD and then for testing robustness.
- QbD for Better Methods
- A QbD Example
By attending this online training course you get full access to the 38 video modules and approximately 12.5 hours of instruction. You also get handouts containing copies of all of the approximately 520 PowerPoint slides used in the class. These are arranged for easy note-taking while you view each module and give you a valuable resource for future reference.
This module has a complementary quiz. By correctly answering the quiz questions for all of the modules as part of the course you will be able to download your certificate of completion. Types of questions to expect are:
- Why is the QbD design space a more desirable method adjustment tool than the USP’s or EPs safety net of adjustment limits?
- What are the advantages of QbD?
- Which approach is the best for developing a QbD method?
- When screening scouting runs for potentially successful conditions, What techniques should be used?
- When no single scouting run condition separates all the peaks, what other chromatographic qualities will help you choose which set of screening conditions should be explored further?
- Why is a set of 4 scouting gradients (two gradients at two temperatures) such a powerful tool for method development?
Analytical Training Solutions, brought to you by Separation Science, is the leading global portal for fundamentals, best practice, troubleshooting and method development training for chromatographic and mass spectrometric techniques. Comprehensive, self-paced online courses and validated learning provides a unique education resource for analytical chemists. Currently, we offer HPLC training, LC-MS training, GC training and GC-MS training.