Application Compendium

Automated High-Throughput Mass Spec: Proven. Rapid. Complete.

Explore how the Agilent RapidFire brings ease of use to high-throughput mass spectrometry and redefines what is possible.

The Agilent RapidFire is the proven choice for high-throughput mass spectrometry, with over 15 years of development and publications. Strategies for automated method development and results in as little as two seconds per sample bring greater efficiency to your laboratory, while temperature-controlled sample storage and plate-handling robotics enable you to focus on outcomes instead of process. Whether you need the quantitative precision and sensitivity of triple quadrupole mass spectrometry or the investigative power of time-of-flight high-resolution mass spectrometry, RapidFire delivers reliable results faster than ever before. Explore how RapidFire brings ease of use to high-throughput mass spectrometry and redefines what is possible.

This 63-page compendium includes the following application notes sub-divided by category:

Method Development

  • High-Throughput (Sub-2.5 Second) Direct Injection Analysis by Mass Spectrometry
  • Automated Method Development Using the Agilent RapidFire High-Throughput Mass Spectrometry System
  • Minimization of the Required Sample Volume for Agilent RapidFire High-Throughput Mass Spectrometry Systems


  • High-Throughput, Ion-Pairing-Free, HILIC Analysis of Oligonucleotides
  • Using Agilent RapidFire Coupled to Quadrupole Time-of-Flight Mass Spectrometry
  • High-Throughput Mass Spectrometry Analysis of Synthetic Oligonucleotides

Drug Discovery

  • Fragment-Based Drug Discovery: Comparing Labeled and Label-Free Screening
  • High-Throughput Lead Discovery with Agilent RapidFire/MS Systems


  • Ultrafast Analysis of In Vitro Microsomal Metabolic Stability using RapidFire Coupled to the Ultivo Triple Quadrupole Mass Spectrometer

Clinical Research

  • Ultrafast Analysis of Levetiracetam in Serum

Forensics and Toxicology

  • Feasibility of the Agilent RapidFire High-Throughput MS System for Ultrafast Screening of Drug Targets

Plus access the bonus content:

[Case Study] Rapid Target Identification in Drug Discovery
Find out how Jnana Therapeutics has streamlined workflows from days to hours with the Agilent RapidFire high-throughput mass spectrometry system.

[Video] Proven. Rapid. Complete. RapidFire 400 — A complete approach to High-Throughput Mass Spectrometry
Gain a distinct competitive advantage and build your drug discovery pipeline faster and more efficiently, for example in ADME in discovery, using the Agilent RapidFire high-throughput mass spectrometry system.


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