The Neurolipid Atlas Project

Learn how a quantitative shotgun lipidomics solution is used for establishing a lipidomics atlas, and mapping cell and disease-specific lipid changes.

By watching this presentation, you will:

  • Learn about the quantitative shotgun lipidomics platform and its application 
  • Find out about necessary hardware and software, and address visualization and application
  • See how this particularly evolves around the Neurolipid Atlas Project and drug development

Event Overview

New evidence from genetic, epidemiology, and cell biology data suggests that lipid and cholesterol metabolism play a role in several neurodegenerative diseases. Despite this, the study of lipid biology remains limited, and there are challenges in applying lipidomic techniques to human tissues. The Neurolipid Atlas Project seeks to examine the lipidome of human iPSC-derived neurons and glia, which have been gene-edited for specific disease variants. The objective is to establish the initial mapping of changes in the human lipidome linked to neurodegenerative diseases, focusing on disease-specific, genotype-specific, and cell type-specific changes.

This presentation discusses the application of a quantitative shotgun lipidomics platform as a key technology for establishing a lipidomics atlas and mapping cell and disease-specific lipid changes.

What you need to know:

Format: On-demand

Duration: Approximately 35 minutes


Martin Giera
Head of Metabolomics Group, Leiden University Medical Center, The Netherlands

Martin Giera, Ph.D., studied pharmacy in Heidelberg and Munich. Martin was a visiting scientist at Harvard Medical School and the Scripps Research Institute. Martin is head of the metabolomics group at the Leiden University Medical Center. He is involved in several multi-national consortia and a member of several editorial boards, and was the chairman of the interdisciplinary committee at FWO. Martin has a keen interest in metabolomics technology, drug development, and biochemistry. He has published more than 175 scientific publications and books.


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