Uncovering Xenobiotics in Nontargeted Analyses using LC-IMS-MS, Mass Defect Analysis and Machine Learning

by | Environmental, Persistent Organic Pollutants


ErinBaker_200This presentation, produced by Separation Science, in collaboration with Agilent, forms part of an on-demand symposium covering new methods in PFAS testing, featuring thought leaders from across the globe. This key talk titled 'Uncovering Xenobiotics in Nontargeted Analyses using Ion Mobility Spectrometry, Mass Defect Analysis and Machine Learning' given by Erin S. Baker, Ph.D (Associate Professor, North Carolina State University, USA) is now available to watch. Below is an outline of the presentation:

Format: On-demand Presentation

The identification of xenobiotics in nontargeted analyses is a vital step in understanding human exposure. Xenobiotic metabolism, excretion, and co-existence with other endogenous molecules however greatly complicates nontargeted studies. This presentation demonstrates how combining mass defect analysis, machine learning and liquid chromatography, ion mobility spectrometry and mass spectrometry (LC-IMS-MS) separations enables an in-depth understanding of molecular responses occurring due to chemical exposures.

By watching this presentation you will learn about:

  • The power of multidimensional LC-IMS-MS platforms for nontargeted analyses.
  • The utility of multidimensional libraries for narrowing down potential feature identifications.
  • LC-IMS-MS capabilities for improving the detection, identification and validation of endogenous and xenobiotic features.

Register to watch this presentation by clicking on the button below:

In addition, you'll also gain access to a series of presentations unique to this on-demand symposium:

AddPres_ChenLatest Regulations & Standards on PFAS Testing in the Materials Industry
Dr Yuhong Chen (Global Materials Segment, Applied Markets, Agilent Technologies)

AddPres_GilSampling and Analysis of Volatile PFAS in Air by TD-GC-MS
Carlos Gil (Business Development Manager, Markes International GmbH)

AddPres_BaumannStreamlined PFAS Annotation and Visualization with FluoroMatch Flow and Visualizer
Stephen Baumann (Application Applied Segment Manager, Agilent Technologies)

AddPres_ThaxtonUsing Thermal Desorption and GC-MS/MS for the Analysis of PFAS Compounds in Air for Improved Detectability & Reliability
Kurt Thaxton (Gerstel)

As well as download the following educational assets...

PFAS2022_Resource1Your Guide to Targeted Quantification & Screening of PFAS Compounds in Environmental Matrices

AgilentPFAS_Resource2Get your lab up to speed for PFAS analysis with the Agilent start-to-finish drinking and surface water eMethod

AgilentPFAS2022_Resource3Customer Testimonial: Watch How Sanexen Environmental Services Meets Client Needs for PFAS Testing

AgilentPFAS2022_Resource4Get Ahead and Stay Ahead with Comprehensive Workflows for Extraction, Screening, Quantification, and Reporting of PFAS in Water Samples

AgilentPFAS2022_Resource5Meet the Challenges of PFAS Soil Testing in an Evolving Regulatory Framework With Start-to-Finish Workflows


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Published  Nov 29, 2022

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