[eBook] Pharmaceutical and biopharmaceutical solutions

by | Aug 17, 2021

Discover an effective method for drug quantitation in biological fluids, a high-throughput analysis for simple fractionation and more...

This eBook contains a selection of application notes relevant for pharmaceutical and biopharmaceutical analysis using HPLC / (U)HPLC or LC-MS/MS.

Shimadzu_Pharma_Biopharma_eBook_CoverDiscover an effective method for drug quantitation in biological fluids, a high-throughput analysis for simple fractionation, the application of a dual injection system for the analysis of pharmaceuticals, together with methods for impurity analysis and comprehensive fractionation. 

Applications include:

  • Ultra-Fast LC-MS/MS Analysis of Drugs in Biological Fluids
  • High Efficiency in Workflow from Preparative HPLC to Analytical HPLC
  • Application of a Dual Injection (U)HPLC for the Analysis of Pharmaceuticals
  • Impurity Analysis in Pharmaceutical Products Using Diode Array Detection
  • Comprehensive Fractionation of Herbal Medicine Components by PDA-ELSD Triggered Preparative LC

Learning Outcomes for each Application Note

Ultra-Fast LC-MS/MS Analysis of Drugs in Biological Fluids

  • Ultrafast autosampler reduces overall analysis times for higher throughput
  • Carryover is kept to an absolute minimum with active rinsing

High Efficiency in Workflow from Preparative HPLC to Analytical HPLC

  • Liquid handler is equipped with parallel preparative and analytical flow paths, enabling seamless re-analysis of the collected fractions
  • Automated processes increase efficiency for the entire workflow, from fractionation to re-analysis

Application of a Dual Injection (U)HPLC for the Analysis of Pharmaceuticals

  • Dual injection technique allows two analyses to be run simultaneously, doubling throughput
  • Shows the successful method transfer to superficially porous (SPP) columns

Impurity Analysis in Pharmaceutical Products Using Diode Array Detection

  • PDA detector eliminates the effects of stray light during detection
  • Delivers outstanding performance over a wide range of concentrations

Comprehensive fractionation can be performed without missing non-UV absorbing compounds

  • Graphical user interface provides easy and labor-saving operation for fractionation settings
  • Smooth transfer from preliminary analytical LC to preparative purification LC is possible

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