Perform absolute characterization of polymeric excipients

by | Apr 25, 2019

Discover how light scattering with size-exclusion chromatography can help in your polymer analytical characterization.

Do you encounter challenges with polymer characterization and would like to learn more about cutting-edge technology that can help identify and overcome any shortfalls of your current techniques? If so, this presentation from Separation Science, in collaboration with Wyatt Technology, can help you achieve this goal.


Polymeric and other content can contribute up to 90% of the total mass in a pharmaceutical product, where excipients play a critical role in the drug’s performance.  In just one example of the importance of excipient properties for therapeutic effect, the molar mass and degree of branching in polymeric excipients directly impact the rate of drug release. In this presentation Andrew Meyers shows how conventional characterization techniques including size-exclusion chromatography (SEC) and bulk viscosity measurements may fall short. The addition of light scattering analysis provides complete characterization of molar mass, viscosity, branching, conformation, conjugation, and size of excipients and other polymers. 

By viewing this presentation you will learn...

  • Principles of MALS detection and calculation of polymer molecular size and mass
  • Identifying and overcoming shortfalls of conventional GPC/SEC
  • Leveraging DLS and viscosity for enhanced characterization of molecular size
  • Calculation of copolymer ratios and molecular weights in-line with SEC
  • Advantages of FFF for separation of branched polymers.

The Presenter

AndrewMeyerAndrew Meyer completed his Ph.D. in Applied Science – Polymer Chemistry from the College of William and Mary in Virginia, studying under Professor David Kranbuehl. His doctoral research centered on life monitoring of high performance polyamides used for offshore oil recovery, employing SEC-MALS for molar mass characterization in parallel with viscometry, rheometry, tensile testing, and other mechanical testing of the bulk polymers.
Dr. Meyer joined Wyatt Technology in 2001, serving for several years as an Applications Scientist, then as Dean of Wyatt's "Light Scattering University" and as Director of Customer Service & Support. Currently, he is responsible for sales and support in Wyatt's Southeast Region, introducing Wyatt's innovative technologies there, determining which instruments best match customer requirements, and ensuring complete customer satisfaction with all of Wyatt's products throughout the region.

Related Content