Protein Binding Determination – Comparison Study of Techniques & Devices
A comparative study between the Supel™ BioSPME 96-Pin device and the rapid equilibrium dialysis technique.
Pharma Drug Discovery
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Advances in Mass Spectrometry Instrument Intelligence
Learn how to develop LC/MS methods faster, ensure confidence in results and maximize uptime.
Analysis of Oligonucleotides by SEC-MALS
Introducing a size exclusion chromatography column that can be used to distinguish between oligonucleotide species differing by one base in length.
Synthetic Carbon Adsorbents for Removal of Host Cell Proteins in Monoclonal Antibody Purification
Learn how to deplete difficult-to-remove lower molecular weight and hydrophobic HCPs and get a high mAb yield.
Fast Analysis of Intact Therapeutic Monoclonal Antibody Trastuzumab
This article demonstrates a high-resolution and reproducible analysis of mAb trastuzumab in less than 5 minutes using a BIOshell™ A400 Protein C4 column
Minimization of the Required Sample Volume for Agilent RapidFire High-Throughput Mass Spectrometry System
Find out how the use of the Agilent RapidFire high-throughput MS system with tubing using a smaller id enables sample volume to be minimized.
High-Throughput Lead Discovery with Agilent RapidFire/MS Systems
In this application note a stearoyl-coenzyme A desaturase (SCD) assay is used to illustrate the power of Agilent RapidFire/MS systems for screening intractable targets.
Automated Method Development Using a High‑Throughput Mass Spectrometry System
Discover a procedure for optimizing a method for a small example molecule, cyclic AMP with the final method having a CV of <3%, greatly improved peak shape,...
Ultrafast Analysis of Levetiracetam in Serum
This application note evaluates the ability of an ultrafast SPE/MS/MS system to analyze levetiracetam in human serum.
Fragment-Based Drug Discovery: Comparing Labeled and Label-Free Screening
This application note describes screening of β-amyloid secretase (BACE-1) using fluorescence spectroscopy and ultrafast SPE/MS/MS.
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