Separation Science, in collaboration with Thermo Fisher Scientific, offers a selection of application notes relevant for biopharmaceutical analysis. Discover the latest advances in high-resolution accurate-mass (HRAM) mass spectrometry. Learn more about the routine characterization of biotherapeutics through LC-MS peptide mapping and how to achieve improved targeted peptide quantification.

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Characterization of IgG1 monoclonal antibody (mAb) oxidation variants at intact, subunit and peptide levels
Download application brief about the identification and localization of methionine oxidation of biotherapeutics via LC-MS analysis at the intact protein, subunit and peptide levels.


Sensitive profiling of IgG1 monoclonal antibody variants under native conditions
Download application brief about biopharmaceutical applications involving separation under native conditions and performance for intact high-resolution accurate-mass (HRAM) mass analysis.


Confident peptide mapping and disulfide bond analysis of an IgG2 monoclonal antibody
Download application brief about the routine characterization of biotherapeutics through LC-MS peptide mapping with high-resolution accurate-mass (HRAM) MS/MS identification.


Improving targeted peptide quantification: Combining a Thermo Scientific TSQ Altis MS with a FAIMS Pro interface for peptides in complex matrices
Combining the Thermo Scientific™ FAIMS Pro™ interface with triple-stage quadrupole (TSQ) technology increases the dynamic range and enables accurate quantification of peptides at low levels even from complex matrices.

Published  Feb 23, 2021

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