Effectively separate and characterize complex (bio)macromolecular architectures

by | Bioclinical, Biopharma, Pharmaceutical

Do you need to to interpret and evaluate distributions of size and conformation in complex (bio)macromolecular systems? Would you like to characterize and understand complex polymers and nanostructures? If so, this presentation from Separation Science, in collaboration with Wyatt Technology, will help you achieve your goal. 


Soft materials such as highly-branched, responsive or dynamic polymers have great potential for advanced applications. The basis for this potential is the versatility, tunability and high functionality of the polymer systems and of their well-defined nanoscale structures. Understanding these materials and how to adjust their scaling parameters on a molecular level is crucial for controlled design to meet application requirements.
In this presentation, Albena Lederer compares techniques for characterizing the properties and interactions of highly-functionalized polymers, highly-branched polymers, biohybrids and similar complex systems. These techniques include field-flow fractionation coupled to multiple types of detectors, and complementary methods such as AFM, cryo-TEM and MD simulations. She also goes on to discuss the relation between conformation and interactions, which is highly relevant for biological applications.

The presenter

AlbenaLederer_WebAlbena Lederer received her Ph.D. in Physical Chemistry in 1999 from the Max-Planck-Institute of Polymer Research Mainz and the University Mainz. In 2000 she joined the Leibniz-Institut für Polymerforschung Dresden receiving her habilitation degree in Physical Chemistry from the Technishe Universität Dresden in 2010. Currently she is a head of the Polymer Separation Group at the Leibniz-Institut für Polymerforschung Dresden, privatdozent at the Technische Universität Dresden and extraordinary Professor at the Stellenbosch University, South Africa. Her research interests are in the field of polymer analysis with special focus on advanced separation and scattering techniques. Her current activities are related to the nanostructural aspects of dendritic polymers, novel separation techniques and intermolecular interactions of for branched and biofunctional architectures, and in situ characterization of responsive polymer systems.

Published  Apr 24, 2019

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