In this article we’ll look at flow-rate and particle-size adjustments.
In prior instalments of this series on method adjustment, we’ve looked at the guidelines from the European Pharmacopoeia (EP) and United States Pharmacopoeia (USP) for allowable adjustments in pH (Part 1), mobile phase (Part 2), and column dimensions (Part 3). In this article we’ll look at flow-rate and particle-size adjustments.
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