Difluoroacetic Acid as an Effective Mobile Phase Modifier for the LC-UV/MS Analysis of Proteins
Difluoroacetic acid (DFA) is discussed as a suitable alternative to TFA and FA in the LC-UV/MS analysis of proteins.
Pharma Biologics & Biosimilars
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Extractables Study with LC-UV/MS
An LC-UV/MS method is presented using a corresponding E&L certified reference material (CRM) mix for LC screening containing 21 extractables that can typically be found.
Three Methods for Critical Quality Attribute Determination of Monoclonal Antibodies
Three step-by-step protocols to monitor critical quality attributes (CQAs) of monoclonal antibodies were developed using adalimumab as an example.
An Optimized Protocol for Peptide Mapping of Therapeutic Monoclonal Antibodies
The optimized protocol introduced in this article shows a shorter incubation time, less artifact formation, and an efficient separation of tryptic digests
Methods for mAb and ADC analysis
Application notes outlining methods for monoclonal antibody and antibody-drug conjugate analysis.
Download now the Bioanalysis Quantitation Applications eBook Vol 2
Explore how to approach therapeutic quantitation with this ebook on lab-tested analysis methods for Small Molecules, Proteins, Biomarkers and Gene Therapies.
Phospholipid Analysis for Four Types of Mouse Tissues using Triple Quadrupole LC-MS/MS with SimLipid
Precursor ion scan (PIS) or neutral loss scan (NLS) with a triple quadrupole LC-MS was used to compare the phospholipid profiles of four mouse tissues.
Advances in online viscometry to increase sensitivity and dynamic range
Find out more about advances in online viscometry and how a new differential viscometer dramatically improves sensitivity and near immunity to pump pulses
How to analyse cysteine-linked ADC using HIC
Hydrophobic interaction chromatography (HIC) is used for the determination of drug-to-antibody ratio (DAR) of a cysteine-linked antibody drug conjugate (ADC).
Essential applications for (U)HPLC analysis of biomolecules
Tosoh Bioscience has produced a biopharmaceutical application notebook covering applications for HPLC and UHPLC analysis of biomolecules
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