Difluoroacetic acid (DFA) is discussed as a suitable alternative to TFA and FA in the LC-UV/MS analysis of proteins.
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An LC-UV/MS method is presented using a corresponding E&L certified reference material (CRM) mix for LC screening containing 21 extractables that can typically be found.
Three step-by-step protocols to monitor critical quality attributes (CQAs) of monoclonal antibodies were developed using adalimumab as an example.
The optimized protocol introduced in this article shows a shorter incubation time, less artifact formation, and an efficient separation of tryptic digests
Application notes outlining methods for monoclonal antibody and antibody-drug conjugate analysis.
Explore how to approach therapeutic quantitation with this ebook on lab-tested analysis methods for Small Molecules, Proteins, Biomarkers and Gene Therapies.
Phospholipid Analysis for Four Types of Mouse Tissues using Triple Quadrupole LC-MS/MS with SimLipid
Precursor ion scan (PIS) or neutral loss scan (NLS) with a triple quadrupole LC-MS was used to compare the phospholipid profiles of four mouse tissues.
Find out more about advances in online viscometry and how a new differential viscometer dramatically improves sensitivity and near immunity to pump pulses
Hydrophobic interaction chromatography (HIC) is used for the determination of drug-to-antibody ratio (DAR) of a cysteine-linked antibody drug conjugate (ADC).
Tosoh Bioscience has produced a biopharmaceutical application notebook covering applications for HPLC and UHPLC analysis of biomolecules
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